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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Neuronal acetylcholine receptor; alpha4/beta2 partial agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Alcohol Drinking; Alzheimer Disease; Amphetamine-Related Disorders; Cocaine-Related Disorders; Friedreich Ataxia; Machado-Joseph Disease; Marijuana Abuse; Parkinson Disease; Psychotic Disorders; Substance-Related Disorders; Acute Coronary Syndrome; Alcoholism; Dry Eye Syndromes; Lung Neoplasms; Neoplasms; Schizophrenia; Smoking Cessation; Tobacco Use Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 1,3-beta-glucan synthase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Mycoses; Neutropenia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms; Aspergillosis; Candidiasis, Invasive; Neuroaspergillosis; Candidemia; Candidiasis; Peritonitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sunscreen
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Melanosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Restless Legs Syndrome; Supranuclear Palsy, Progressive; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel protein type IV alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Hypertension, Pulmonary; Kidney Diseases; Myotonic Disorders; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Cardiomyopathy, Dilated; Crohn Disease; Heart Failure, Diastolic; Irritable Bowel Syndrome; Long QT Syndrome; Vascular Diseases; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: INHALATION; NASAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; PEDIATRICS; RESPIRATORY
THERAPEUTIC INDICATION: Pulmonary Disease, Chronic Obstructive; Chronic Disease; Hypersensitivity; Severe Acute Respiratory Syndrome; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 51 inhibitor
ROUTE OF ADMINISTRATION: INTRAVENOUS; ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Chagas Disease; Granulomatous Disease, Chronic; Mucormycosis; Candidiasis, Oral; Coccidioidomycosis; Leukopenia; Mycoses; Aspergillosis; Candidiasis; Neutropenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Burns; Lymphoma, Non-Hodgkin; Candidiasis, Vulvovaginal; Conjunctivitis, Inclusion; Helicobacter Infections; Periodontitis; Vaginosis, Bacterial; Bacterial Infections; Eye Infections; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Gliosarcoma; Hemorrhagic Fever, Ebola; Leukemia, Myeloid, Acute; Osteosarcoma; Adenocarcinoma; Adrenal Cortex Neoplasms; Ascites; Brain Neoplasms; Carcinoid Tumor; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Lung Neoplasms; Melanoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Pheochromocytoma; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Sarcoma, Alveolar Soft Part; Small Cell Lung Carcinoma; Stomach Neoplasms; Thymoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; von Hippel-Lindau Disease; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors; Kidney Neoplasms; Prostatic Neoplasms; Urogenital Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Endothelin receptor, ET-A/ET-B antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Asthma; Heart Failure, Diastolic; Proteinuria; Renal Insufficiency, Chronic; Hypertension, Pulmonary; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D2 receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Obsessive-Compulsive Disorder; Anxiety; Autistic Disorder; Bipolar Disorder; Dementia; Depressive Disorder; Psychotic Disorders; Schizophrenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cannabinoid CB1 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Marijuana Abuse; Pain; Spinal Cord Injuries; Alcohol Drinking; Tobacco Use Disorder; Arteriosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Diabetes Mellitus, Type 2; Fatty Liver; Lipid Metabolism Disorders; Metabolic Syndrome; Prader-Willi Syndrome; Prediabetic State; Smoking Cessation; Weight Loss; Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sunscreen
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: C-C chemokine receptor type 5 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Hypertriglyceridemia; AIDS Dementia Complex; Arthritis, Rheumatoid; Cognitive Dysfunction; Graft vs Host Disease; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Sarcoma, Kaposi; Severe Acute Respiratory Syndrome; Stroke; Acquired Immunodeficiency Syndrome; Infections; Autoimmune Diseases; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Endothelin receptor, ET-A/ET-B antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Anemia, Sickle Cell; Altitude Sickness; Asthma; Hypoplastic Left Heart Syndrome; Severe Acute Respiratory Syndrome; Idiopathic Pulmonary Fibrosis; Vascular Diseases; Familial Primary Pulmonary Hypertension; Hypertension; Hypertension, Pulmonary; Pulmonary Arterial Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Coronary Artery Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Renal Cell; Endometrial Neoplasms; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency, Chronic; Thyroid Neoplasms; Adenocarcinoma; Brain Neoplasms; Carcinoma, Ductal; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Glioma; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Pituitary Neoplasms; Stomach Neoplasms; Uterine Cervical Neoplasms; Brain Diseases; Breast Neoplasms; Head and Neck Neoplasms; Sarcoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic; Acute Coronary Syndrome; Atherosclerosis; Diabetic Nephropathies; Kidney Diseases; Atrial Fibrillation; Coronary Artery Disease; Diabetes Mellitus; Essential Hypertension; Glomerulonephritis, IGA; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Marfan Syndrome; Myocardial Infarction; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin inhibitor
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Astrocytoma; Gliosarcoma; Head and Neck Neoplasms; Breast Neoplasms, Male; Burkitt Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Verrucous; Colorectal Neoplasms; Fallopian Tube Neoplasms; Hypopharyngeal Neoplasms; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Melanoma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Tongue Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Endometrial Neoplasms; Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amphetamine-Related Disorders; Cocaine-Related Disorders; Multiple Sclerosis; Bipolar Disorder; Depressive Disorder; Feeding and Eating Disorders; Attention Deficit Disorder with Hyperactivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine transporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Esophageal Neoplasms; Glioma; Multiple Sclerosis; Neoplasms; Schizophrenia; Sleep Initiation and Maintenance Disorders; Stroke; Brain Injuries; Depressive Disorder; Disorders of Excessive Somnolence; Fatigue; Obesity; Attention Deficit Disorder with Hyperactivity; Narcolepsy; Sleep Apnea, Obstructive; Sleep Wake Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Chordoma; Huntington Disease; Cerebellar Ataxia; Giant Cell Tumors; Glioma; Graft vs Host Disease; Hypertension, Pulmonary; Leukemia, Myeloid, Acute; Melanoma; Neurilemmoma; Parkinson Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Synovitis, Pigmented Villonodular; Alzheimer Disease; Gastrointestinal Stromal Tumors; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Sarcoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: FK506-binding protein 1A inhibitor
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Adenocarcinoma; Astrocytoma; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma; Colonic Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Genital Neoplasms, Female; Glioma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lung Neoplasms; Oligodendroglioma; Peritoneal Neoplasms; Prostatic Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Adenoma; Arthritis, Rheumatoid; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Glioblastoma; Gliosarcoma; Hodgkin Disease; Insulinoma; Ischemia; Kidney Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Peripheral Arterial Disease; Prostatic Neoplasms, Castration-Resistant; Retroviridae Infections; Sarcoma; Small Cell Lung Carcinoma; Somatostatinoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Hepatoblastoma; Lymphoma; Lymphoma, Mantle-Cell; Neoplasm Metastasis; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Carcinoma, Renal Cell; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Renin inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypertension; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: D2-like dopamine receptor agonist
ROUTE OF ADMINISTRATION: TRANSDERMAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Alzheimer Disease; Fibromyalgia; Stroke; Parkinson Disease; Restless Legs Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hepatitis C; Leukemia, Biphenotypic, Acute; HTLV-I Infections; Liver Cirrhosis, Biliary; Multiple Sclerosis, Relapsing-Remitting; Acquired Immunodeficiency Syndrome; HIV Infections; Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Idiopathic Pulmonary Fibrosis; Essential Hypertension; Stroke; Hypertension; Marfan Syndrome; Severe Acute Respiratory Syndrome; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Radiodermatitis; Alzheimer Disease; Autistic Disorder; Enteritis; Hypertension, Portal; Lesch-Nyhan Syndrome; Liver Cirrhosis; Phenylketonurias; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Colorectal Neoplasms; Asthma; Dermatitis; Dermatitis, Atopic; Eczema; Rhinitis; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor; Urticaria; Hypersensitivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Meningitis; Appendicitis; Cholecystitis; Pancreatitis; Peritonitis; Pneumonia; Pneumonia, Ventilator-Associated; Bacterial Infections; Intraabdominal Infections; Pyelonephritis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Dry Eye Syndromes; Cataract; Panuveitis; Uveitis; Inflammation; Uveitis, Anterior
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Transient receptor potential cation channel subfamily A member 1 opener
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetic Neuropathies; Tobacco Use Disorder; Deglutition Disorders; Hypertension; Stomach Neoplasms; Arthralgia; Arthritis; Asthma; Back Pain; Bronchitis; Burns; Bursitis; Common Cold; Contusions; Cough; Eczema; Headache; Hemorrhoids; Herpes Labialis; Insect Bites and Stings; Muscle Cramp; Myalgia; Nasal Obstruction; Oral Ulcer; Osteoarthritis; Pain; Pharyngitis; Pruritus; Sprains and Strains; Sunburn; Tendinopathy; Wounds and Injuries
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Colonic Neoplasms; Stomach Neoplasms; Rectal Neoplasms; Esophageal Neoplasms; Anemia; Colorectal Neoplasms; Osteosarcoma