MITOXANTRONE HYDROCHLORIDE

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Search structure


Trade Names	MITOXANTRONE HYDROCHLORIDE NOVANTRONE
Synonyms	CL 232,315 CL-232315 Mitoxantrone Dihcl Mitoxantrone Dihydrochloride Mitoxantrone dihydrochloride Mitoxantrone hcl Mitoxantrone hydrochloride Mitozantrone NSC-301739 Novantrone
Status
Molecule Category	Salt-form
UNII	U6USW86RD0
EPA CompTox	DTXSID0045173
Parent Compound:	MITOXANTRONE

Structure


InChI Key	ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21
InChI	InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H30Cl2N4O6
Molecular Weight	517.41
AlogP	-0.14
Hydrogen Bond Acceptor	10.0
Hydrogen Bond Donor	8.0
Number of Rotational Bond	12.0
Polar Surface Area	163.18
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	32.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action	Action	Reference
DNA inhibitor	INHIBITOR	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase PIM family	-	50.9	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	7.2-900	-	-	-
Trypanosoma brucei brucei	-	2.4	-	-	-

Target Conservation


Protein: DNA topoisomerase II alpha Description: DNA topoisomerase 2-alpha Organism : Homo sapiens P11388 ENSG00000131747

Cross References

Resources	Reference
ChEBI	50727
ChEMBL	CHEMBL1417019
FDA SRS	U6USW86RD0
Guide to Pharmacology	7242
KEGG	C11195
PDB	MIX
PubChem	51082
SureChEMBL	SCHEMBL3928
ZINC	ZINC03794794

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025