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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Nicotinic acetylcholine receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Lice Infestations
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Coagulation factor X inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; HEMATOLOGY; OTHER
THERAPEUTIC INDICATION: Blood Coagulation Disorders; Obesity, Morbid; Renal Insufficiency, Chronic; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Antiphospholipid Syndrome; Aortic Valve Stenosis; Coronary Disease; Diabetes Mellitus, Type 2; Hematoma; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Peripheral Arterial Disease; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Stroke; Thrombocytopenia; Venous Thromboembolism; Atrial Fibrillation; Pulmonary Embolism; Thrombosis; Venous Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hepatitis C; Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA-directed RNA polymerase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL
THERAPEUTIC INDICATION: Clostridium Infections; Diarrhea; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: KCNQ (Kv7) potassium channel opener
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Depressive Disorder; Depressive Disorder, Major; Neuralgia, Postherpetic; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: RESPIRATORY
THERAPEUTIC INDICATION: Multiple Sclerosis; Pancreatitis; Alveolitis, Extrinsic Allergic; Bronchiolitis Obliterans; Burns; Cardiomyopathy, Hypertrophic; Glomerulosclerosis, Focal Segmental; Heart Failure; Leiomyoma; Liver Cirrhosis; Lung Diseases, Interstitial; Nephrotic Syndrome; Neurofibromatosis 1; Proteinuria; Pulmonary Fibrosis; Radiation Pneumonitis; Renal Insufficiency; Renal Insufficiency, Chronic; Scleroderma, Systemic; Severe Acute Respiratory Syndrome; Diabetic Foot; Keloid; Pneumoconiosis; Pneumonia; Respiratory Distress Syndrome; Idiopathic Pulmonary Fibrosis; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Parkinson Disease; Multiple System Atrophy; Parkinsonian Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Type-1 angiotensin II receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Hypertension; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Asthma; Heart Failure; Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alcohol Drinking; Anxiety; Arthritis, Rheumatoid; Celiac Disease; Gingivitis; Acne Vulgaris; Amyotrophic Lateral Sclerosis; Burns; Chemical and Drug Induced Liver Injury; Hidradenitis Suppurativa; Ileus; Intervertebral Disc Degeneration; Severe Acute Respiratory Syndrome; Tinea Pedis; Cardiovascular Diseases; Dental Caries; Hemorrhoids; Infections; Pain; Periodontitis; Tension-Type Headache; Tooth Diseases; Multiple Sclerosis; Short Bowel Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Marijuana Abuse; Memory Disorders; Stress Disorders, Post-Traumatic; Anxiety Disorders; Depressive Disorder, Major; Depressive Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Phosphodiesterase 5A inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Kidney Diseases; Erectile Dysfunction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Leprosy; Mycobacterium avium-intracellulare Infection; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tuberculosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cystic fibrosis transmembrane conductance regulator positive modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: RESPIRATORY
THERAPEUTIC INDICATION: Liver Diseases; Bronchitis, Chronic; Ciliary Motility Disorders; Pulmonary Disease, Chronic Obstructive; Cystic Fibrosis; Respiratory Tract Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pulmonary Disease, Chronic Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Smoothened homolog inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Glioblastoma; Multiple Myeloma; Primary Myelofibrosis; Prostatic Neoplasms; Basal Cell Nevus Syndrome; Breast Neoplasms; Carcinoma, Pancreatic Ductal; Chondrosarcoma, Clear Cell; Chondrosarcoma, Mesenchymal; Glioma; Gliosarcoma; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Medulloblastoma; Meningioma; Ovarian Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Carcinoma, Basal Cell; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR
THERAPEUTIC INDICATION: Breast Neoplasms; Lipid Metabolism Disorders; Adenoma; Alzheimer Disease; Colonic Neoplasms; Non-alcoholic Fatty Liver Disease; Cardiovascular Diseases; Severe Acute Respiratory Syndrome; Hypertriglyceridemia; Pancreatitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dermatomyositis; Granulomatous Disease, Chronic; Kidney Diseases; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Renal Insufficiency, Chronic; Sarcoidosis; Scleroderma, Systemic; Alopecia Areata; Colitis; Crohn Disease; Dermatitis, Atopic; Dry Eye Syndromes; Granuloma, Lethal Midline; Myositis; Pneumonia; Polymyalgia Rheumatica; Pouchitis; Sjogren's Syndrome; Wounds and Injuries; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Glioblastoma; Psoriasis; Severe Acute Respiratory Syndrome; Spondylitis, Ankylosing; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Anoctamin-1 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dihydroorotate dehydrogenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: MUSCULOSKELETAL; OTHER
THERAPEUTIC INDICATION: Celiac Disease; Kidney Diseases; Paraparesis, Tropical Spastic; Immune System Diseases; Multiple Sclerosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 3A inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Carcinoma, Pancreatic Ductal; Insulin Resistance; Malaria; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Acquired Immunodeficiency Syndrome; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; HIV Infections; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Prostanoid FP receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases; Kidney Diseases; Liver Diseases; Marijuana Abuse; Substance-Related Disorders; Cocaine-Related Disorders; Opioid-Related Disorders; Peripheral Nervous System Diseases; Tobacco Use Disorder; Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperlipoproteinemia Type II; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Discoidin domain-containing receptor 2 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL; OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Biliary Tract Neoplasms; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Bile Duct Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Glioblastoma; Hemangiosarcoma; Liposarcoma; Macular Degeneration; Melanoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alzheimer Disease; Cognitive Dysfunction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: ATP synthase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: RESPIRATORY
THERAPEUTIC INDICATION: Tuberculosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Myelodysplastic Syndromes; Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Stromal Tumors; Glioblastoma; Leukemia; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Thyroid Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glutamate receptor ionotropic AMPA antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
THERAPEUTIC INDICATION: Alcoholism; Bipolar Disorder; Depressive Disorder, Major; Stress Disorders, Post-Traumatic; Torticollis; Amyotrophic Lateral Sclerosis; Diabetic Neuropathies; Essential Tremor; Migraine Disorders; Neuralgia; Peripheral Nervous System Diseases; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Parkinson Disease; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Pancreatic Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Lymphoma, Mantle-Cell; Ovarian Neoplasms; Severe Acute Respiratory Syndrome; Urinary Bladder Neoplasms; Uterine Neoplasms; Breast Neoplasms; Neoplasms; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 integrase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Squamous Cell; Gliosarcoma; Leukemia, Myeloid, Acute; Liver Diseases; Multiple Myeloma; Urogenital Neoplasms; Adenocarcinoma, Follicular; Adrenal Cortex Neoplasms; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma; Carcinoma, Neuroendocrine; Cholangiocarcinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Kidney Neoplasms; Melanoma; Meningioma; Neuroendocrine Tumors; Osteosarcoma; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Thyroid Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Beta-3 adrenergic receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Polycystic Ovary Syndrome; Cerebral Hemorrhage; Heart Failure; Hypertrophy, Left Ventricular; Pain; Prediabetic State; Urinary Bladder, Neurogenic; Cystitis, Interstitial; Kidney Calculi; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge