PERAMPANEL

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC N03AX22
UNII H821664NPK
EPA CompTox DTXSID80191501

Structure

InChI Key PRMWGUBFXWROHD-UHFFFAOYSA-N
Smiles N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O
InChI
InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H15N3O
Molecular Weight 349.39
AlogP 4.44
Hydrogen Bond Acceptor 4.0
Number of Rotational Bond 3.0
Polar Surface Area 58.68
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 27.0

Pharmacology

Mechanism of Action Action Reference
Glutamate receptor ionotropic AMPA antagonist ANTAGONIST Expert
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor AMPA receptor
- 243-623 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 243-623 - - -
Rattus norvegicus
- 60-93 - - -

Target Conservation

Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 1
Organism : Homo sapiens
P42261 ENSG00000155511
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 2
Organism : Homo sapiens
P42262 ENSG00000120251
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 3
Organism : Homo sapiens
P42263 ENSG00000125675
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 4
Organism : Homo sapiens
P48058 ENSG00000152578

Cross References

Resources Reference
ChEBI 71013
ChEMBL CHEMBL1214124
DrugBank DB08883
DrugCentral 4684
FDA SRS H821664NPK
Guide to Pharmacology 7050
PDB 6ZP
PubChem 9924495
SureChEMBL SCHEMBL194370
ZINC ZINC000030691797
CONTENTS