EZOGABINE

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Search structure


Trade Names	POTIGA
Synonyms	AWD-21360 AWD21-360 D-23129 Ezogabine GKE-841 GW-582892X GW582892X Potiga Retigabine Trobalt WAY-143841
Status
Molecule Category	Free-form
UNII	12G01I6BBU
EPA CompTox	DTXSID40164615

Structure


InChI Key	PCOBBVZJEWWZFR-UHFFFAOYSA-N
Smiles	CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N
InChI	InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H18FN3O2
Molecular Weight	303.34
AlogP	3.59
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	76.38
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
KCNQ (Kv7) potassium channel opener	OPENER	FDA PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	350-930	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	350-930	-	-	-	-

Cross References

Resources	Reference
ChEBI	68584
ChEMBL	CHEMBL41355
DrugBank	DB04953
DrugCentral	4181
FDA SRS	12G01I6BBU
Guide to Pharmacology	2601
KEGG	C13826
PDB	FBX
PubChem	121892
SureChEMBL	SCHEMBL20835
ZINC	ZINC000000016154

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025