EcoDrugPlus


Synonyms	(18F)AV-45 18F-AV-45 18f-av45 AV-45 F-18 Amyvid Av45 f-18 Florbetapir (18f) Florbetapir f 18 Florbetapir f-18 Florbetapir(18-f) Florbetapir, f-18
Status
Molecule Category	Free-form
UNII	6W15Z5R0RU
EPA CompTox	DTXSID80241898


InChI Key	YNDIAUKFXKEXSV-CRYLGTRXSA-N
Smiles	CNc1ccc(/C=C/c2ccc(OCCOCCOCC[18F])nc2)cc1
InChI	InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1

Property Name	Value
Molecular Formula	C20H25FN2O3
Molecular Weight	359.43
AlogP	3.68
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	12.0
Polar Surface Area	52.61
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
Diagnostic agent	None	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor	-	-	-	2.87-2.9	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	2.87-2.9	-

Resources	Reference
ChEBI	66880
ChEMBL	CHEMBL1774461
DrugBank	DB09149
DrugCentral	4285
FDA SRS	6W15Z5R0RU
Guide to Pharmacology	7344
SureChEMBL	SCHEMBL14826096
ZINC	ZINC000100090643

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FLORBETAPIR F 18

Structure

Physicochemical Descriptors

Pharmacology

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