LORCASERIN

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Synonyms
Status
Molecule Category Free-form
ATC A08AA11
UNII 637E494O0Z
EPA CompTox DTXSID3048659

Structure

InChI Key XTTZERNUQAFMOF-QMMMGPOBSA-N
Smiles C[C@H]1CNCCc2ccc(Cl)cc21
InChI
InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H14ClN
Molecular Weight 195.69
AlogP 2.59
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Polar Surface Area 12.03
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 13.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
1.82-943 - - 1.3-257 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Canis lupus familiaris
16.2 - - - -
Homo sapiens
1.82-943 - - 1.3-220 -
Rattus norvegicus
- - - - 34-82

Cross References

Resources Reference
ChEBI 65353
ChEMBL CHEMBL360328
DrugBank DB04871
DrugCentral 4374
FDA SRS 637E494O0Z
Guide to Pharmacology 2941
PubChem 11658860
SureChEMBL SCHEMBL169382
ZINC ZINC000006733300
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