APRACLONIDINE HYDROCHLORIDE

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Search structure


Trade Names	APRACLONIDINE HYDROCHLORIDE IOPIDINE
Synonyms	AL-02145 AL02145 Aplonidine hydrochloride Apraclonidine hcl Apraclonidine hydrochloride Iopidine
Status
Molecule Category	Salt-form
UNII	D2VW67N38H
EPA CompTox	DTXSID6045749

Structure


InChI Key	OTQYGBJVDRBCHC-UHFFFAOYSA-N
Smiles	Cl.Nc1cc(Cl)c(N=C2NCCN2)c(Cl)c1
InChI	InChI=1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H11Cl3N4
Molecular Weight	281.57
AlogP	1.76
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	1.0
Polar Surface Area	62.44
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	15.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-2 agonist	AGONIST	DailyMed

Target Conservation


Protein: Adrenergic receptor alpha-2 Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha-2 Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286











Protein: Adrenergic receptor alpha-2 Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160

Cross References

Resources	Reference
ChEBI	2789
ChEMBL	CHEMBL1200379
FDA SRS	D2VW67N38H
Guide to Pharmacology	7117
KEGG	C07668
PubChem	51763
SureChEMBL	SCHEMBL41138
ZINC	ZINC00057175

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025