TERAZOSIN HYDROCHLORIDE

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Search structure


Trade Names	HYTRIN TERAZOSIN HYDROCHLORIDE
Synonyms	ABBOTT-45975 ABBOTT-45975 ANHYDROUS Benph Heitrin Hytracin Hytrin Hytrin bph Itrin NSC-759168 Terazosin (as hydrochloride) Terazosin hcl Terazosin hcl 2h20 Terazosin hydrochloride Terazosin hydrochloride anhydrous Terazosin hydrochloride dihydrate
Status
Molecule Category	Salt-form
UNII	D32S14F082
Parent Compound:	TERAZOSIN

Structure


InChI Key	NZMOFYDMGFQZLS-UHFFFAOYSA-N
Smiles	COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC.Cl.O.O
InChI	InChI=1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H30ClN5O6
Molecular Weight	459.93
AlogP	1.06
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	103.04
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-1 antagonist	ANTAGONIST	DailyMed

Target Conservation


Protein: Adrenergic receptor alpha-1 Description: Alpha-1D adrenergic receptor Organism : Homo sapiens P25100 ENSG00000171873











Protein: Adrenergic receptor alpha-1 Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907











Protein: Adrenergic receptor alpha-1 Description: Alpha-1B adrenergic receptor Organism : Homo sapiens P35368 ENSG00000170214

Cross References

Resources	Reference
ChEBI	9446
ChEMBL	CHEMBL3989562
FDA SRS	D32S14F082
Guide to Pharmacology	7302
KEGG	C07127
PubChem	63016
SureChEMBL	SCHEMBL41544
ZINC	ZINC01271441

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025