OXCARBAZEPINE


Trade Names	OXCARBAZEPINE OXTELLAR XR TRILEPTAL
Synonyms	GP-47680 KIN-493 NSC-758693 Oxcarbamazepine Oxcarbazepine Oxtellar xr SPN-804 Trileptal
Status
Molecule Category	Free-form
ATC	N03AF02
UNII	VZI5B1W380
EPA CompTox	DTXSID0045703


InChI Key	CTRLABGOLIVAIY-UHFFFAOYSA-N
Smiles	NC(=O)N1c2ccccc2CC(=O)c2ccccc21
InChI	InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)

Mechanism of Action	Action	Reference
Sodium channel alpha subunit blocker	BLOCKER	PubMed PubMed DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel P2X receptor	-	-	-	-	10
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	31.2-76.2
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	71.5-85.1

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	71.5-85.1
Homo sapiens	-	-	-	-	10-33
Rattus norvegicus	-	-	-	-	31.2-76.2


Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314












Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873








Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531










Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253









Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356







Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876











Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313

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