Trade Names | |
Synonyms | |
Status | |
Molecule Category | UNKNOWN |
ATC | N03AF02 |
UNII | VZI5B1W380 |
EPA CompTox | DTXSID0045703 |
InChI Key | CTRLABGOLIVAIY-UHFFFAOYSA-N |
---|---|
Smiles | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C15H12N2O2 |
Molecular Weight | 252.27 |
AlogP | 2.64 |
Hydrogen Bond Acceptor | 2.0 |
Hydrogen Bond Donor | 1.0 |
Number of Rotational Bond | 0.0 |
Polar Surface Area | 63.4 |
Molecular species | NEUTRAL |
Aromatic Rings | 2.0 |
Heavy Atoms | 19.0 |
Mechanism of Action | Action | Reference |
---|---|---|
Sodium channel alpha subunit blocker | BLOCKER | PubMed PubMed DailyMed |
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313 |
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Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Ion channel
Ligand-gated ion channel
P2X receptor
|
- | - | - | - | 10 | |
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | - | - | - | 31-76 | |
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 72 |
Resources | Reference |
---|---|
ChEBI | 7824 |
ChEMBL | CHEMBL1068 |
DrugBank | DB00776 |
DrugCentral | 2017 |
FDA SRS | VZI5B1W380 |
Human Metabolome Database | HMDB0014914 |
Guide to Pharmacology | 7254 |
KEGG | C07492 |
PharmGKB | PA450732 |
PubChem | 34312 |
SureChEMBL | SCHEMBL35129 |
ZINC | ZINC000000004724 |