EcoDrugPlus


Synonyms	(r)-bis(poc)pmpa Bis-poc-pmpa GS-4331 Tenofovir bis(isopropyloxycarbonyloxymethyl) ester Tenofovir disoproxil Viread
Status
Molecule Category	Free-form
ATC	J05AF07
UNII	F4YU4LON7I
EPA CompTox	DTXSID5052757


InChI Key	JFVZFKDSXNQEJW-CQSZACIVSA-N
Smiles	CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)OCOC(=O)OC(C)C
InChI	InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1

Property Name	Value
Molecular Formula	C19H30N5O10P
Molecular Weight	519.45
AlogP	3.04
Hydrogen Bond Acceptor	15.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	13.0
Polar Surface Area	185.44
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	35.0

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Hepatitis B virus	880	-	-	-	-
Human immunodeficiency virus 1	16	-	-	-	-
Human immunodeficiency virus type 2 (ISOLATE ROD)	13	-	-	-	-

Resources	Reference
ChEBI	63717
ChEMBL	CHEMBL1538
DrugBank	DB00300
DrugCentral	2593
FDA SRS	F4YU4LON7I
PubChem	5481350
SureChEMBL	SCHEMBL52793
ZINC	ZINC000003929022

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

TENOFOVIR DISOPROXIL

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Physicochemical Descriptors

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