EcoDrugPlus


Trade Names	MELOXICAM MOBIC QMIIZ ODT VIVLODEX
Synonyms	Acticam Anjeso Contacera Coxicam Emdocam Flexicam Inflacam Loxicom Melfax Melosus Melovem Meloxicam Meloxidolor Meloxidyl Meloxivet
Status
Molecule Category	Free-form
ATC	M01AC06
UNII	VG2QF83CGL
EPA CompTox	DTXSID1020803

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

Search:

Exact

Similarity

SubStructure

Threshold (%) >= 70


InChI Key	ZRVUJXDFFKFLMG-UHFFFAOYSA-N
Smiles	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1
InChI	InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H13N3O4S2
Molecular Weight	351.41
AlogP	1.95
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	99.6
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	23.0

Mechanism of Action	Action	Reference
Cyclooxygenase-2 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	151.36-700	-	-	-7-77
Epigenetic regulator Writer Protein methyltransferase SET domain	-	-	-	-	18-29

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cercopithecidae	-	160	-	-	-7-77
Homo sapiens	-	330-700	-	-	18-56
Mus musculus	-	151.36	-	-	-
Rattus norvegicus	-	-	-	-	20.8-61.88

Target Conservation


Protein: Cyclooxygenase-2 Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Environmental Exposure

Countries
Czech Republic
Slovakia

Cross References

Resources	Reference
ChEBI	6741
ChEMBL	CHEMBL599
DrugBank	DB00814
DrugCentral	1676
FDA SRS	VG2QF83CGL
Human Metabolome Database	HMDB0014952
Guide to Pharmacology	7220
KEGG	C08169
PDB	MXM
PubChem	54677470
SureChEMBL	SCHEMBL23589638
ZINC	ZINC000013129998

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MELOXICAM

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Environmental Exposure

Cross References