Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method
|
Homo sapiens
|
10.3
nM
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
|
Homo sapiens
|
5.1
nM
|
|
Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method after 1 hr of incubation
|
Homo sapiens
|
35.2
nM
|
|
Mean inhibitory constant towards human carbonic anhydrase V determined by spectrophotometric dansylamide binding assay
|
Homo sapiens
|
20.6
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay
|
Helicobacter pylori
|
231.0
nM
|
|
Inhibition of human recombinant CA1
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Helicobacter pylori recombinant CA
|
Helicobacter pylori
|
218.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
5.0
nM
|
|
Inhibition of human carbonic anhydrase 2
|
Homo sapiens
|
47.6
nM
|
|
Inhibition of human carbonic anhydrase 5A
|
Homo sapiens
|
20.6
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis H37Rv
|
208.0
nM
|
|
Inhibition of human cloned CA1 by CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human cloned CA2 by CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant CA5A by CO2 hydration assay
|
Homo sapiens
|
20.0
nM
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
|
Saccharomyces cerevisiae
|
106.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
89.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
|
Mus musculus
|
634.0
nM
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes at 20 uM
|
Homo sapiens
|
48.0
%
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay
|
Candida albicans
|
942.0
nM
|
|
Inhibition of Cryptococcus neoformans recombinant Can2 by stopped-flow CO2 hydration assay
|
Cryptococcus neoformans
|
971.0
nM
|
|
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
35.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
|
Stylophora pistillata
|
259.0
nM
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay
|
Homo sapiens
|
20.0
nM
|
|
Inhibition of human recombinant CA2 by stopped-flow hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
876.0
nM
|
|
Inhibition of human cloned CA1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human cloned CA2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assay
|
Homo sapiens
|
5.0
nM
|
|
Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay
|
Homo sapiens
|
20.0
nM
|
|
Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
89.0
nM
|
|
Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
430.0
nM
|
|
Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay
|
Mus musculus
|
634.0
nM
|
|
Selectivity ratio of Ki for human CA2 to Ki for human CA14
|
Homo sapiens
|
250.0
nM
|
|
Inhibition of human FAAH at 1 uM
|
Homo sapiens
|
-17.9
%
|
|
Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 Phe91Asn mutant expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method
|
Homo sapiens
|
13.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
259.0
nM
|
|
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
645.0
nM
|
|
Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3
|
Brucella suis
|
406.0
nM
|
|
Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay
|
Homo sapiens
|
20.0
nM
|
|
Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5
|
Leptonychotes weddellii
|
517.0
nM
|
|
Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
210.0
nM
|
|
Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
|
Candida albicans
|
940.0
nM
|
|
Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
|
Cryptococcus neoformans
|
970.0
nM
|
|
Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant full length CA1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant full length CA2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human CA9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Astrosclera willeyana
|
165.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
303.0
nM
|
|
Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
68.1
nM
|
|
Inhibition of human wild type carbonic anhydrase 2 Leu204Ser mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Homo sapiens
|
57.3
nM
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Cryptococcus neoformans
|
971.0
nM
|
|
Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Candida albicans
|
942.0
nM
|
|
Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Vibrio cholerae
|
982.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay
|
Trypanosoma cruzi
|
867.0
nM
|
|
Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Candida glabrata
|
114.0
nM
|
|
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Sulfurihydrogenibium yellowstonense
|
140.0
nM
|
|
Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Helicobacter pylori
|
231.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
117.0
nM
|
|
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Thalassiosira weissflogii
|
404.0
nM
|
|
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
157.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
157.0
nM
|
|
Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
5.1
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-1 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
831.0
nM
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
820.0
nM
|
|
Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
254.0
nM
|
|
Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Helicobacter pylori Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Helicobacter pylori
|
254.0
nM
|
|
Inhibition of Porphyromonas gingivalis Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
345.0
nM
|
|
Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
157.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay
|
Plasmodium falciparum
|
246.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Porphyromonas gingivalis
|
157.0
nM
|
|
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Nostoc commune
|
85.6
nM
|
|
Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Anopheles gambiae
|
263.0
nM
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay
|
Nostoc commune
|
85.6
nM
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase by CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
490.0
nM
|
|
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of weddell seal alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leptonychotes weddellii
|
517.0
nM
|
|
Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Chionodraco hamatus
|
52.9
nM
|
|
Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Sulfurihydrogenibium yellowstonense
|
140.0
nM
|
|
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Thiomicrospira crunogena XCL-2
|
411.0
nM
|
|
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
982.0
nM
|
|
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
157.0
nM
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Nostoc commune
|
85.6
nM
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
490.0
nM
|
|
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Colwellia psychrerythraea
|
771.0
nM
|
|
Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Enterobacter sp.
|
128.0
nM
|
|
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
725.0
nM
|
|
Inhibition of voltage dependent T-type Ca2+ channel in Wistar rat cerebral cortex assessed as reduction in transient inward Ca2+ current at -60 mV holding potential at 500 uM by whole-cell patch clamp method relative to control
|
Rattus norvegicus
|
60.0
%
|
|
Inhibition of voltage dependent T-type Ca2+ channel in mouse N1E-115 cells assessed as reduction in transient inward Ca2+ current at 50 uM by whole-cell patch clamp method relative to control
|
Mus musculus
|
40.0
%
|
|
Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
35.0
nM
|
|
Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Vibrio cholerae
|
725.0
nM
|
|
Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
35.0
nM
|
|
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600)
|
Staphylococcus aureus subsp. aureus
|
1.04
%
|
|
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600)
|
Escherichia coli
|
0.42
%
|
|
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600)
|
Klebsiella pneumoniae
|
12.91
%
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600)
|
Pseudomonas aeruginosa
|
11.37
%
|
|
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600
|
Acinetobacter baumannii
|
10.49
%
|
|
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630
|
Candida albicans
|
3.7
%
|
|
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570)
|
Cryptococcus neoformans
|
-5.53
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
16.73
%
|
|
Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
56.0
nM
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
35.0
nM
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
10.77
%
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
7.575
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.01
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.05
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.01
%
|
|
Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
|
Homo sapiens
|
250.0
nM
|
|
Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
|
Homo sapiens
|
10.4
nM
|
|
Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
|
Homo sapiens
|
0.9
nM
|
|
Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.8
nM
|
|