Trade Names
Synonyms
Status
Molecule Category UNKNOWN
ATC N03AX15
UNII 459384H98V
EPA CompTox DTXSID9046023

Structure

InChI Key UBQNRHZMVUUOMG-UHFFFAOYSA-N
Smiles NS(=O)(=O)Cc1noc2ccccc12
InChI
InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H8N2O3S
Molecular Weight 212.23
AlogP 1.85
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 2.0
Polar Surface Area 87.18
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 14.0

Bioactivity

Mechanism of Action Action Reference
Sodium channel alpha subunit blocker BLOCKER PubMed DailyMed
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 1 subunit alpha

Organism : Homo sapiens

P35498 ENSG00000144285
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 4 subunit alpha

Organism : Homo sapiens

P35499 ENSG00000007314
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 5 subunit alpha

Organism : Homo sapiens

Q14524 ENSG00000183873
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 9 subunit alpha

Organism : Homo sapiens

Q15858 ENSG00000169432
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 2 subunit alpha

Organism : Homo sapiens

Q99250 ENSG00000136531
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 3 subunit alpha

Organism : Homo sapiens

Q9NY46 ENSG00000153253
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 11 subunit alpha

Organism : Homo sapiens

Q9UI33 ENSG00000168356
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 8 subunit alpha

Organism : Homo sapiens

Q9UQD0 ENSG00000196876
Protein: Sodium channel alpha subunit

Description: Sodium channel protein type 10 subunit alpha

Organism : Homo sapiens

Q9Y5Y9 ENSG00000185313
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - -
Enzyme Lyase
- 1860 21 10-6800 -
Enzyme Oxidoreductase
- 24800 - 2900 -
Enzyme
- 1860 21 10-6800
Assay Description Organism Bioactivity Reference
Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method Homo sapiens 10.3 nM
Inhibitory constant against catalytic domain of human carbonic anhydrase IX Homo sapiens 5.1 nM
Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method after 1 hr of incubation Homo sapiens 35.2 nM
Mean inhibitory constant towards human carbonic anhydrase V determined by spectrophotometric dansylamide binding assay Homo sapiens 20.6 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay Helicobacter pylori 231.0 nM
Inhibition of human recombinant CA1 Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 Homo sapiens 35.0 nM
Inhibition of Helicobacter pylori recombinant CA Helicobacter pylori 218.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay Homo sapiens 5.0 nM
Inhibition of human carbonic anhydrase 2 Homo sapiens 47.6 nM
Inhibition of human carbonic anhydrase 5A Homo sapiens 20.6 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay Mycobacterium tuberculosis H37Rv 208.0 nM
Inhibition of human cloned CA1 by CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human cloned CA2 by CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human recombinant CA5A by CO2 hydration assay Homo sapiens 20.0 nM
Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay Saccharomyces cerevisiae 106.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay Homo sapiens 89.0 nM
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay Homo sapiens 5.1 nM
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay Mus musculus 634.0 nM
Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes at 20 uM Homo sapiens 48.0 %
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method Homo sapiens 35.0 nM
Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay Candida albicans 942.0 nM
Inhibition of Cryptococcus neoformans recombinant Can2 by stopped-flow CO2 hydration assay Cryptococcus neoformans 971.0 nM
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay Helicobacter pylori 35.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method Homo sapiens 56.0 nM
Inhibition of human recombinant CA1 by stopped-flow CO2 assay Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 by stopped-flow CO2 assay Homo sapiens 35.0 nM
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay Stylophora pistillata 259.0 nM
Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay Homo sapiens 20.0 nM
Inhibition of human recombinant CA2 by stopped-flow hydration assay Homo sapiens 35.0 nM
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay Mycobacterium tuberculosis 876.0 nM
Inhibition of human cloned CA1 by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human cloned CA2 by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assay Homo sapiens 5.0 nM
Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay Homo sapiens 20.0 nM
Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay Homo sapiens 89.0 nM
Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay Homo sapiens 117.0 nM
Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay Homo sapiens 5.1 nM
Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay Homo sapiens 430.0 nM
Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay Mus musculus 634.0 nM
Selectivity ratio of Ki for human CA2 to Ki for human CA14 Homo sapiens 250.0 nM
Inhibition of human FAAH at 1 uM Homo sapiens -17.9 %
Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 1 Phe91Asn mutant expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method Homo sapiens 13.0 nM
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method Homo sapiens 35.0 nM
Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay Stylophora pistillata 259.0 nM
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay Stylophora pistillata 645.0 nM
Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 Homo sapiens 35.0 nM
Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3 Brucella suis 406.0 nM
Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay Homo sapiens 20.0 nM
Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 Homo sapiens 35.0 nM
Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5 Leptonychotes weddellii 517.0 nM
Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay Mycobacterium tuberculosis 210.0 nM
Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay Candida albicans 940.0 nM
Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay Cryptococcus neoformans 970.0 nM
Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method Homo sapiens 35.0 nM
Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method Homo sapiens 117.0 nM
Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay Homo sapiens 35.0 nM
Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay Homo sapiens 117.0 nM
Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human recombinant full length CA1 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant full length CA2 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human CA9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 5.1 nM
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay Astrosclera willeyana 165.0 nM
Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay Homo sapiens 303.0 nM
Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay Homo sapiens 68.1 nM
Inhibition of human wild type carbonic anhydrase 2 Leu204Ser mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay Homo sapiens 57.3 nM
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method Homo sapiens 35.0 nM
Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method Cryptococcus neoformans 971.0 nM
Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method Candida albicans 942.0 nM
Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay Homo sapiens 56.0 nM
Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay Homo sapiens 35.0 nM
Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay Homo sapiens 117.0 nM
Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay Homo sapiens 5.1 nM
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay Vibrio cholerae 982.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay Trypanosoma cruzi 867.0 nM
Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay Candida glabrata 114.0 nM
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay Sulfurihydrogenibium yellowstonense 140.0 nM
Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay Helicobacter pylori 231.0 nM
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay Homo sapiens 35.0 nM
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay Homo sapiens 56.0 nM
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 117.0 nM
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay Homo sapiens 5.1 nM
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay Homo sapiens 117.0 nM
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 117.0 nM
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Thalassiosira weissflogii 404.0 nM
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Porphyromonas gingivalis 157.0 nM
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay Porphyromonas gingivalis 157.0 nM
Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay Homo sapiens 5.1 nM
Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-1 assessed as CO2 hydrase activity by stopped-flow assay Legionella pneumophila subsp. pneumophila str. Philadelphia 1 831.0 nM
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay Legionella pneumophila subsp. pneumophila str. Philadelphia 1 820.0 nM
Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay Helicobacter pylori 254.0 nM
Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method Homo sapiens 56.0 nM
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method Homo sapiens 35.0 nM
Inhibition of Helicobacter pylori Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method Helicobacter pylori 254.0 nM
Inhibition of Porphyromonas gingivalis Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method Porphyromonas gingivalis 345.0 nM
Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method Porphyromonas gingivalis 157.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay Plasmodium falciparum 246.0 nM
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay Porphyromonas gingivalis 157.0 nM
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay Nostoc commune 85.6 nM
Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay Anopheles gambiae 263.0 nM
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay Nostoc commune 85.6 nM
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase by CO2 hydration assay Pseudoalteromonas haloplanktis 490.0 nM
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method Homo sapiens 35.0 nM
Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of weddell seal alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay Leptonychotes weddellii 517.0 nM
Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay Chionodraco hamatus 52.9 nM
Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay Homo sapiens 35.0 nM
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay Sulfurihydrogenibium yellowstonense 140.0 nM
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay Thiomicrospira crunogena XCL-2 411.0 nM
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay Vibrio cholerae 982.0 nM
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay Homo sapiens 35.0 nM
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Porphyromonas gingivalis 157.0 nM
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Nostoc commune 85.6 nM
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Pseudoalteromonas haloplanktis 490.0 nM
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay Colwellia psychrerythraea 771.0 nM
Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay Homo sapiens 35.0 nM
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay Enterobacter sp. 128.0 nM
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay Vibrio cholerae 725.0 nM
Inhibition of voltage dependent T-type Ca2+ channel in Wistar rat cerebral cortex assessed as reduction in transient inward Ca2+ current at -60 mV holding potential at 500 uM by whole-cell patch clamp method relative to control Rattus norvegicus 60.0 %
Inhibition of voltage dependent T-type Ca2+ channel in mouse N1E-115 cells assessed as reduction in transient inward Ca2+ current at 50 uM by whole-cell patch clamp method relative to control Mus musculus 40.0 %
Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis Homo sapiens 35.0 nM
Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis Vibrio cholerae 725.0 nM
Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay Homo sapiens 56.0 nM
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay Homo sapiens 35.0 nM
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600) Staphylococcus aureus subsp. aureus 1.04 %
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600) Escherichia coli 0.42 %
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600) Klebsiella pneumoniae 12.91 %
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600) Pseudomonas aeruginosa 11.37 %
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600 Acinetobacter baumannii 10.49 %
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630 Candida albicans 3.7 %
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570) Cryptococcus neoformans -5.53 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Homo sapiens 16.73 %
Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay Homo sapiens 56.0 nM
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay Homo sapiens 35.0 nM
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 10.77 % SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate Severe acute respiratory syndrome coronavirus 2 7.575 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.01 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.05 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus -0.05 % Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Chlorocebus sabaeus 0.01 %
Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay Homo sapiens 250.0 nM
Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay Homo sapiens 10.4 nM
Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay Homo sapiens 0.9 nM
Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay Homo sapiens 3.8 nM

Cross References

Resources Reference
ChEBI 10127
ChEMBL CHEMBL750
DrugBank DB00909
DrugCentral 2872
FDA SRS 459384H98V
Human Metabolome Database HMDB0015045
Guide to Pharmacology 7047
KEGG C07504
PDB ZON
PharmGKB PA451978
PubChem 5734
SureChEMBL SCHEMBL35458
ZINC ZINC000000004321