PARGYLINE HYDROCHLORIDE

/static/temp/default.svg Search structure
Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII W70V6I2OMY
EPA CompTox DTXSID1044647

Structure

InChI Key BCXCABRDBBWWGY-UHFFFAOYSA-N
Smiles C#CCN(C)Cc1ccccc1.Cl
InChI
InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H14ClN
Molecular Weight 195.69
AlogP 1.75
Hydrogen Bond Acceptor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 3.24
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 12.0

Pharmacology

Mechanism of Action Action Reference
Monoamine oxidase inhibitor INHIBITOR PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Epigenetic regulator Eraser Lysine demethylase Lysine-specific demethylase
- - - - 68.8
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 99.32-133.95
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 99.32-133.95
Homo sapiens
- - - - 68.8
Rattus norvegicus
- - - - 45-78

Target Conservation

Protein: Monoamine oxidase
Description: Amine oxidase [flavin-containing] A
Organism : Homo sapiens
P21397 ENSG00000189221
Protein: Monoamine oxidase
Description: Amine oxidase [flavin-containing] B
Organism : Homo sapiens
P27338 ENSG00000069535

Cross References

Resources Reference
ChEMBL CHEMBL1200425
FDA SRS W70V6I2OMY
Guide to Pharmacology 7262
KEGG C07414
PubChem 9373
SureChEMBL SCHEMBL121111
CONTENTS