HALOPROGIN

/static/temp/default.svg

Search structure


Trade Names	HALOTEX
Synonyms	Haloprogin Halotex M-1028 Mycanden NSC-100071
Status
Molecule Category	Free-form
ATC	D01AE11
UNII	AIU7053OWL
EPA CompTox	DTXSID9046865

Structure


InChI Key	CTETYYAZBPJBHE-UHFFFAOYSA-N
Smiles	Clc1cc(Cl)c(OCC#CI)cc1Cl
InChI	InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H4Cl3IO
Molecular Weight	361.39
AlogP	4.42
Hydrogen Bond Acceptor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	9.23
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	14.0

Pharmacology

Mechanism of Action	Action	Reference
Cell membrane inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	500	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	600	-	-	-	-
Homo sapiens	-	500	-	-	-
Trypanosoma brucei	300	-	-	-	-

Cross References

Resources	Reference
ChEBI	5614
ChEMBL	CHEMBL1289
DrugBank	DB00793
DrugCentral	1355
FDA SRS	AIU7053OWL
Human Metabolome Database	HMDB0014931
KEGG	D00339
PharmGKB	PA164768737
PubChem	3561
SureChEMBL	SCHEMBL3649
ZINC	ZINC000001530649

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025