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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Endothelin receptor ET-A antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Subarachnoid Hemorrhage
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dipeptidyl peptidase IV inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alzheimer Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Interleukin-8 receptor A modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pemphigoid, Bullous; Diabetes Mellitus, Type 1
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cystic Fibrosis; Renal Insufficiency, Chronic; Pain; Renal Insufficiency
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cannabinoid CB1 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bronchial Diseases; Cardiovascular Diseases; Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase ABL inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Serine/threonine-protein kinase Aurora-B inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leukemia, Myeloid; Lymphoma; Neoplasms; Leukemia, Myeloid, Acute
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin stabiliser
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Glioblastoma; Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Colonic Neoplasms; Kidney Neoplasms; Melanoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Plasma kallikrein inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Angioedemas, Hereditary
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cicatrix
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anxiety; Dementia; Depressive Disorder; Psychotic Disorders; Schizophrenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D1 receptor partial agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dipeptidyl peptidase IV inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Neoplasms; Diabetes Mellitus; Diabetes Mellitus, Type 2; Kidney Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Epidermal growth factor receptor erbB1 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Mastocytosis; Arthritis, Rheumatoid; Hypersensitivity; Urticaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Peroxisome proliferator-activated receptor alpha agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lipid Metabolism Disorders; Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase JAK1 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Hepatocellular; Endometrial Neoplasms; Hematologic Diseases; Leukemia, Prolymphocytic, T-Cell; Lung Neoplasms; Lymphoma; Melanoma; Pancreatic Neoplasms; Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Colitis, Ulcerative; Hematologic Neoplasms; Hodgkin Disease; Lymphohistiocytosis, Hemophagocytic; Myeloproliferative Disorders; Neoplasms; Primary Myelofibrosis; Pruritus; Psoriasis; Scleroderma, Systemic; Graft vs Host Disease; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel protein type IX alpha subunit blocker
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bipolar Disorder; Diabetic Neuropathies; Erythromelalgia; Neuralgia; Radiculopathy; Trigeminal Neuralgia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial DNA gyrase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Supplement
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Carcinoma, Basal Cell; Cerebellar Ataxia; Charcot-Marie-Tooth Disease; Epidermolysis Bullosa; Gliosarcoma; Lichen Planus, Oral; Amyotrophic Lateral Sclerosis; Bipolar Disorder; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Coronary Disease; Death, Sudden, Cardiac; Depressive Disorder; Diabetes Mellitus, Type 1; Glioblastoma; Heart Arrest; Heart Failure; Heart Failure, Diastolic; Pancreatic Neoplasms; Polycystic Ovary Syndrome; Prader-Willi Syndrome; Sepsis; Severe Acute Respiratory Syndrome; Supranuclear Palsy, Progressive; Cardiovascular Diseases; Fatigue Syndrome, Chronic; Huntington Disease; Mitochondrial Diseases; Multiple Organ Failure; Muscular Dystrophy, Duchenne; Parkinson Disease; Pre-Eclampsia; Renal Insufficiency, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dental Caries; Hernia, Ventral; Infections; Sinusitis; Burns; Tooth Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Type-1 angiotensin II receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperlipidemias; Kidney Diseases; Cardiovascular Diseases; Essential Hypertension; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H2 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Gastritis; Stomach Ulcer; Gastroesophageal Reflux; Peptic Ulcer
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acute Kidney Injury; Severe Acute Respiratory Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hepatitis C, Chronic; Hepatitis C
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GMP synthase [glutamine-hydrolyzing] inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Lupus Nephritis; Nephrotic Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adenosine A3 receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hepatitis C, Chronic; Carcinoma, Hepatocellular; Non-alcoholic Fatty Liver Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown