EcoDrugPlus


Synonyms	NSC-758679 Telenzepine
Status
Molecule Category	Free-form
UNII	0990EG3K10
EPA CompTox	DTXSID5045209

Synonyms

NSC-758679

Telenzepine

Status

Molecule Category

Free-form

UNII

0990EG3K10

EPA CompTox

DTXSID5045209


InChI Key	VSWPGAIWKHPTKX-UHFFFAOYSA-N
Smiles	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O
InChI	InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)

InChI Key

VSWPGAIWKHPTKX-UHFFFAOYSA-N

Smiles

Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O

InChI

InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)

Property Name	Value
Molecular Formula	C19H22N4O2S
Molecular Weight	370.48
AlogP	2.53
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	55.89
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Property Name

Value

Molecular Formula

C19H22N4O2S

Molecular Weight

370.48

AlogP

2.53

Hydrogen Bond Acceptor

5.0

Hydrogen Bond Donor

1.0

Number of Rotational Bond

2.0

Polar Surface Area

55.89

Molecular species

NEUTRAL

Aromatic Rings

2.0

Heavy Atoms

26.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor	-	-	-	1.8-50.3	-

Targets

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor

1.8-50.3

Resources	Reference
CAS NUMBER	80880-90-6
ChEBI	92110
ChEMBL	CHEMBL253978
FDA SRS	0990EG3K10
Guide to Pharmacology	8594
PubChem	5387
SureChEMBL	SCHEMBL49345
ZINC	ZINC000019796161

Resources

Reference

CAS NUMBER

ChEBI

ChEMBL

FDA SRS

Guide to Pharmacology

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026

TELENZEPINE

Structure

Physicochemical Descriptors

Pharmacology

Cross References