JNJ-38877605

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Search structure


Synonyms	Jnj-38877605
Status
Molecule Category	Free-form
UNII	15UDG410PN
EPA CompTox	DTXSID20677253

Structure


InChI Key	JRWCBEOAFGHNNU-UHFFFAOYSA-N
Smiles	Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1
InChI	InChI=1S/C19H13F2N7/c1-27-11-13(10-23-27)16-6-7-17-24-25-18(28(17)26-16)19(20,21)14-4-5-15-12(9-14)3-2-8-22-15/h2-11H,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H13F2N7
Molecular Weight	377.36
AlogP	3.21
Hydrogen Bond Acceptor	7.0
Number of Rotational Bond	3.0
Polar Surface Area	73.79
Molecular species	NEUTRAL
Aromatic Rings	5.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Hepatocyte growth factor receptor inhibitor	INHIBITOR	Other PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family	-	0.95-9.5	-	-	70.8-72.2
Unclassified protein	-	8.6	-	-	70.8-72.2

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.95-15.8	-	-	-
Mus musculus	-	8.6-17.6	-	-	70.8-72.2

Target Conservation


Protein: Hepatocyte growth factor receptor Description: Hepatocyte growth factor receptor Organism : Homo sapiens P08581 ENSG00000105976

Cross References

Resources	Reference
ChEBI	91417
ChEMBL	CHEMBL2133806
DrugBank	DB13113
FDA SRS	15UDG410PN
PubChem	46911863
SureChEMBL	SCHEMBL182199
ZINC	ZINC000043170515

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025