EcoDrugPlus

CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 40

Ensembl ID : ENSMUSG00000025004
Gene Symbol: CYP2C40
UniProtKB Entry: E9Q7C8

	Assay organism	Assay description	Assay tissue	Bioactivities	Reference

>Cyp2c40|ENSMUSG00000025004
MPKRKILICECCIKCLECLIIPVSVRRVSMDPFVVLVLCLSFLLVLSLWRQRSARGNLPP GPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHG EEFSGRGRIPVFDKVSTGKGIGFSHGNVWKATRVFTVNTLRNLGMGKRTIENKVQEEAQW LMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSP GCQIFNAVPILIDYCPGSHNKLFKNHTWIKSYLLGKIKEHEESLDVTNPRDFIDYFLIQR RQKNGIEHMDYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVI GRHRSPCMQDRNHMPYTNAMVHEVQRYIDLGPNGVVHEVTCDTKFRNYFIPKGTQVMTSL TSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTT ILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMCFIPVE

Identifier	Resolution	Method	Chain	Positions	Source

Source	Identifier	Method	Positions	confidence_type	Confidence Avg.local score
AlphaFold DB	AF-E0CXY8-F1	Predicted	1-120	pLDDT	82.94
AlphaFold DB	AF-E9Q7C8-F1	Predicted	1-520	pLDDT	89.44
AlphaFold DB	AF-P56657-F1	Predicted	1-491	pLDDT	93.06
AlphaFold DB	AF-E0CYU2-F1	Predicted	1-165	pLDDT	91.12


Expression Atlas	ENSMUSG00000025004
MGI Symbol	MGI:1306815
NCBI gene (formerly Entrezgene)	13099
UniProtKB Gene Name	P56657
UniProtKB Gene Name	P56657
UniProtKB Gene Name	P56657
UniProtKB Gene Name	P56657
WikiGene	13099

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CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 69

Ensembl ID : ENSMUSG00000092008
Gene Symbol: CYP2C69
UniProtKB Entry: A0A494B9A4

	Assay organism	Assay description	Assay tissue	Bioactivities	Reference

>Cyp2c69|ENSMUSG00000092008
MDPFVVLVLCLSFMLLLSLWRQRSARRNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKT YGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKGKGIGFSHGNVW KATRVFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICS IVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRHNKFFKNHTWI KSYLLEKIKEHEESLDVTNPRDFIDYFLIQRRQDKGIEHMEYTIEHLATLVTDLVFGGTE TLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRKHMPYTNAMVHEVQRYVD LGPTSLVHEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLDDNGNFK KSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDTTPKYSGFSKIP PKFQMCFIPVE

Identifier	Resolution	Method	Chain	Positions	Source

Source	Identifier	Method	Resolution	Positions	confidence_type	Confidence Avg.local score
AlphaFold DB	AF-E9PXC3-F1	Predicted		1-491	pLDDT	93.0
AlphaFold DB	AF-A0A494B9A4-F1	Predicted		1-165	pLDDT	90.69


Expression Atlas	ENSMUSG00000092008
MGI Symbol	MGI:3721049
NCBI gene (formerly Entrezgene)	100043108
UniProtKB Gene Name	E9PXC3
UniProtKB Gene Name	E9PXC3
WikiGene	100043108

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CYTOCHROME P450, FAMILY 2. SUBFAMILY C, POLYPEPTIDE 37

Ensembl ID : ENSMUSG00000042248
Gene Symbol: CYP2C37
UniProtKB Entry: P56654

	Assay organism	Assay description	Assay tissue	Bioactivities	Reference

>Cyp2c37|ENSMUSG00000042248
MDPILVLVLTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSKV YGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRFPVFDKATNGMGLAFSKGNVW KNTRRFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICS IIFQDRFDYKDRDFLNLMEKLNEITKILSSPWLQICNTYPALLDYCPGSHKQFFKNYASI KNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQEDGNQPLQNRLEHLAITVTDLFSAGTE TTSTTLRYAILLLLKYPHVTAKVQEEIEHVIGKHRSPCMQDRSRMPYTDAMIHEVQRFID LIPNSLPHEVTSDIKFRNYFIPKGTTVITSLSSVLHDSTEFPNPEKFDPGHFLDENGKFK KSDYFIPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVP PAFQLCFIPS

Identifier	Resolution	Method	Chain	Positions	Source

Source	Identifier	Method	Resolution	Positions	confidence_type	Confidence Avg.local score
AlphaFold DB	AF-P56654-F1	Predicted		1-490	pLDDT	94.06


Expression Atlas	ENSMUSG00000042248
MGI Symbol	MGI:1306806
NCBI gene (formerly Entrezgene)	13096
UniProtKB Gene Name	P56654
WikiGene	13096

Select Keywords:

CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 54

Ensembl ID : ENSMUSG00000067225
Gene Symbol: CYP2C54
UniProtKB Entry: Q6XVG2

	Assay organism	Assay description	Assay tissue	Bioactivities	Reference

>Cyp2c54|ENSMUSG00000067225
MDPILVLVLTLSCLFLLSLWRQSYERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSRV YGPVYTLYLGRKPTVVLHGYEAVKEALVDHGDVFAGRGRLPVFDKATNGMGIGFSNGSVW KNTRHFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICS IIFQDRFDYKDRDFLNLLEKLDEISKILSTPWLQVCNTFPALLDYCPGSHNQFFKNYAYI KNFLLEKIREHKESLDVTIPRDFIDYFLIKGAQEDDNHPLKNNFEHLAITVTDLFIGGTE SMSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTNAMIHEVQRFID LVPNNLPHEVTCDIKFRNYFIPKGTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFK KSDYFMPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDITPMLIGLGSVP PAFQLCFIPS

Identifier	Resolution	Method	Chain	Positions	Source

Source	Identifier	Method	Resolution	Positions	confidence_type	Confidence Avg.local score
AlphaFold DB	AF-Q6XVG2-F1	Predicted		1-490	pLDDT	94.44


Expression Atlas	ENSMUSG00000067225
MGI Symbol	MGI:3642960
NCBI gene (formerly Entrezgene)	404195
UniProtKB Gene Name	Q6XVG2
WikiGene	404195

Select Keywords:

CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 50

Ensembl ID : ENSMUSG00000054827
Gene Symbol: CYP2C50
UniProtKB Entry: Q91X77

	Assay organism	Assay description	Assay tissue	Bioactivities	Reference

>Cyp2c50|ENSMUSG00000054827
MDPILVLVFTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQINVKDICQSFTNLSKV YGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFSKGNVW KNTRRFSLTTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICS IIFQDRFDYKDRDFLNLMEKLNEITKIMSTPWLQVCNTFPVLLDYCPGSHNKVFKNYACI KNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQENGNYPLKNRLEHLAITVTDLFSAGTE TTSTTLRYALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTDAMIHEVQRFID LVPNSLPHEVTCDIKFRNYFIPKGTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFK KSDYFMPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVP PAFQLCFIPS

Identifier	Resolution	Method	Chain	Positions	Source

Source	Identifier	Method	Resolution	Positions	confidence_type	Confidence Avg.local score
AlphaFold DB	AF-Q91X77-F1	Predicted		1-490	pLDDT	93.38


Expression Atlas	ENSMUSG00000054827
MGI Symbol	MGI:2147497
NCBI gene (formerly Entrezgene)	107141
UniProtKB Gene Name	Q91X77
WikiGene	107141

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EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026