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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Migraine Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H2 receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL
THERAPEUTIC INDICATION: Carcinoma, Medullary; Esophagitis, Peptic; Hypotension, Orthostatic; Immune System Diseases; Neoplasms; Breast Carcinoma In Situ; Breast Neoplasms; Carcinoma, Renal Cell; Helicobacter Infections; Job Syndrome; Leukemia, T-Cell; Postpartum Hemorrhage; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Barrett Esophagus; Cough; Multiple Sclerosis; Stomach Ulcer; Gastroesophageal Reflux; Peptic Ulcer
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dengue; HIV Infections; Infections; Influenza, Human; Leishmaniasis, Cutaneous; Malaria; Malaria, Falciparum; Plague; Respiratory Syncytial Virus Infections; Schistosomiasis; Severe Acute Respiratory Syndrome; Shock; Staphylococcal Infections; Anthrax; Diabetes Mellitus, Type 1; Hookworm Infections; Influenza in Birds; Pneumonia, Pneumococcal; Stomatitis; Tobacco Use Disorder; Heartburn
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA topoisomerase II inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Plasma Cell; Lymphoma, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Peritoneal Neoplasms; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Astrocytoma; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Castleman Disease; Glioblastoma; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Multiple Sclerosis, Relapsing-Remitting; Myasthenia Gravis; Neuromyelitis Optica; Neutropenia; Oligodendroglioma; Opsoclonus-Myoclonus Syndrome; Optic Nerve Glioma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Severe Acute Respiratory Syndrome; Stiff-Person Syndrome; Thymoma; Waldenstrom Macroglobulinemia; Adenocarcinoma of Lung; Adrenal Cortex Neoplasms; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Embryonal; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Choriocarcinoma; Choroid Plexus Neoplasms; Colorectal Neoplasms; Endodermal Sinus Tumor; Ependymoma; Ganglioneuroblastoma; Gestational Trophoblastic Disease; Granuloma, Lethal Midline; HIV Infections; Hepatoblastoma; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Medulloblastoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Osteosarcoma; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Sarcoma, Myeloid; Seminoma; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Thymus Neoplasms; Wilms Tumor; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypersensitivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bile acid receptor FXR agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Irritable Bowel Syndrome; Paraplegia; Xanthomatosis, Cerebrotendinous
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 51 inhibitor
ROUTE OF ADMINISTRATION: TOPICAL; VAGINAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Wasting Syndrome; Hip Fractures; Malnutrition; Eye Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections; Eye Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Alpha-1a adrenergic receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Heart Diseases; Hypertension; Hemangioma; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Chronic Pain; Pulpitis; Back Pain; Pain; Pregnancy; Wounds and Injuries
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Prostatic Neoplasms; Adrenal Gland Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 1, Kir6.2 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; HEMATOLOGY; OTHER
THERAPEUTIC INDICATION: Angina, Stable; Ischemic Stroke; Spinal Cord Injuries; Brain Injuries; Diabetes Mellitus, Type 1; Stroke; Diabetes, Gestational; Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 1, Kir6.2 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Atherosclerosis; Renal Insufficiency, Chronic; Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Hepatocellular; Hodgkin Disease; Kidney Diseases; Pancreatic Neoplasms; Colorectal Neoplasms; Diabetes Mellitus, Type 1; Leishmaniasis; Lymphoma, AIDS-Related; Melanoma; Trypanosomiasis; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Depressive Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Constipation; Opioid-Related Disorders; Wounds and Injuries; Anemia, Sickle Cell; Chronic Pain; Heroin Dependence; Ileus; Low Back Pain; Mucositis; Neoplasms; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Xanthine dehydrogenase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthralgia; Eye Diseases; Myalgia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Monoamine transporter inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pain; Cerebral Hemorrhage; Cocaine-Related Disorders; Sinusitis; Stroke; Tobacco Use Disorder; Hypertension; Pre-Eclampsia; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Releases active oxygen
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Keratosis, Actinic; Infections; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Osmotic laxative
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Psychotic Disorders; Tics; Tourette Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Constipation; Heart Arrest; Heroin Dependence; Restless Legs Syndrome; Rheumatic Diseases; Blood Coagulation Disorders; Chronic Pain; Fractures, Multiple; Head and Neck Neoplasms; Hemorrhage; Mucositis; Neuralgia; Postoperative Complications; Premature Birth; Respiratory Insufficiency; Rotator Cuff Injuries; Stomatitis; Tonsillitis; Adenocarcinoma; Anemia, Sickle Cell; Back Pain; Dyspnea; Kidney Calculi; Leukemia, Myeloid, Acute; Myocardial Infarction; Neonatal Abstinence Syndrome; Neoplasms; Obesity; Opioid-Related Disorders; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Pruritus; Pulmonary Disease, Chronic Obstructive; Renal Colic; Rib Fractures; Scoliosis; Sleep Apnea, Obstructive; Wounds and Injuries; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 3',5'-cyclic phosphodiesterase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Central Nervous System Neoplasms; Depressive Disorder; HIV Infections; Hepatopulmonary Syndrome; Muscular Dystrophy, Duchenne; Schizophrenia; Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Acute Kidney Injury; Behcet Syndrome; Biliary Atresia; Brain Diseases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Depressive Disorder, Major; Diabetic Nephropathies; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fatty Liver; Fibrosis; Head and Neck Neoplasms; Leishmaniasis; Leishmaniasis, Cutaneous; Liver Cirrhosis, Biliary; Malaria, Falciparum; Neoplasms; Non-alcoholic Fatty Liver Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoidosis, Pulmonary; Wounds and Injuries; Brachial Plexus Neuropathies; Endometriosis; Glomerulonephritis; Hepatitis, Alcoholic; Liver Cirrhosis; Liver Failure; Neonatal Sepsis; Nephrotic Syndrome; Osteonecrosis; Renal Insufficiency, Chronic; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Astrocytoma; Brain Neoplasms; Cocaine-Related Disorders; Glioblastoma; Obesity; Respiratory Tract Infections; Sepsis; Asthma; Buruli Ulcer; Depressive Disorder, Major; Erectile Dysfunction; Head and Neck Neoplasms; Mastitis; Periapical Periodontitis; Pneumonia, Bacterial; Tobacco Use Disorder; Tuberculosis; Tuberculosis, Pulmonary; Abscess; Bronchitis, Chronic; Cholecystitis; Enterobacteriaceae Infections; Helicobacter Infections; Infections; Influenza, Human; Otitis Media; Otitis Media, Suppurative; Pneumonia; Severe Acute Respiratory Syndrome; Sinusitis; Urinary Bladder Neoplasms; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arrhythmias, Cardiac
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lung Diseases, Obstructive