LOXAPINE SUCCINATE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII X59SG0MRYU
EPA CompTox DTXSID3045227
Parent Compound:

Structure

InChI Key YQZBAXDVDZTKEQ-UHFFFAOYSA-N
Smiles CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1.O=C(O)CCC(=O)O
InChI
InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H24ClN3O5
Molecular Weight 445.9
AlogP 3.77
Hydrogen Bond Acceptor 4.0
Polar Surface Area 28.07
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 23.0

Pharmacology

Mechanism of Action Action Reference
D2-like dopamine receptor antagonist ANTAGONIST FDA
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 117.84-140.71
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 117.84-140.71

Target Conservation

Protein: Serotonin 2a (5-HT2a) receptor
Description: 5-hydroxytryptamine receptor 2A
Organism : Homo sapiens
P28223 ENSG00000102468
Protein: Serotonin 2c (5-HT2c) receptor
Description: 5-hydroxytryptamine receptor 2C
Organism : Homo sapiens
P28335 ENSG00000147246

Cross References

Resources Reference
ChEBI 6549
ChEMBL CHEMBL1201155
FDA SRS X59SG0MRYU
PubChem 71399
SureChEMBL SCHEMBL41643
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