TOBRAMYCIN

/static/temp/default.svg Search structure
Trade Names
Synonyms
Status
Molecule Category Free-form
ATC J01GB01 S01AA12
UNII VZ8RRZ51VK
EPA CompTox DTXSID8023680

Structure

InChI Key NLVFBUXFDBBNBW-PBSUHMDJSA-N
Smiles NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O
InChI
InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H37N5O9
Molecular Weight 467.52
AlogP -6.3
Hydrogen Bond Acceptor 14.0
Hydrogen Bond Donor 10.0
Number of Rotational Bond 6.0
Polar Surface Area 268.17
Molecular species BASE
Aromatic Rings 0.0
Heavy Atoms 32.0

Pharmacology

Mechanism of Action Action Reference
70S ribosome inhibitor INHIBITOR FDA PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 105.18-197.1
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 105.18-197.1
Escherichia coli
- 6.2-70 - - -
Homo sapiens
- - 430 - -
Pseudomonas aeruginosa
- - - - 92

Related Entries

Cross References

Resources Reference
ChEBI 28864
ChEMBL CHEMBL1747
DrugBank DB00684
DrugCentral 2684
FDA SRS VZ8RRZ51VK
Human Metabolome Database HMDB0014822
Guide to Pharmacology 10930
KEGG C00397
PDB TOY
PharmGKB PA451704
PubChem 36294
SureChEMBL SCHEMBL2838
ZINC ZINC000008214692
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