EcoDrugPlus


Trade Names	GLEOSTINE
Synonyms	CCN-U CCNU Ccnu Ceenu Gleostine Lomustine NSC-79037
Status
Molecule Category	Free-form
ATC	L01AD02
UNII	7BRF0Z81KG
EPA CompTox	DTXSID2023222


InChI Key	GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Smiles	O=NN(CCCl)C(=O)NC1CCCCC1
InChI	InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

Property Name	Value
Molecular Formula	C9H16ClN3O2
Molecular Weight	233.7
AlogP	2.25
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	61.77
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	15.0

Mechanism of Action	Action	Reference
DNA inhibitor	INHIBITOR	FDA

Resources	Reference
ChEBI	6520
ChEMBL	CHEMBL514
DrugBank	DB01206
DrugCentral	1596
FDA SRS	7BRF0Z81KG
Human Metabolome Database	HMDB0015337
Guide to Pharmacology	7214
KEGG	C07079
PharmGKB	PA164749407
PubChem	3950
SureChEMBL	SCHEMBL3995
ZINC	ZINC000003831006

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

LOMUSTINE

Structure

Physicochemical Descriptors

Pharmacology

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