CYTOCHROME P450, FAMILY 11, SUBFAMILY B, POLYPEPTIDE 1
Ensembl ID : ENSMUSG00000075604
Gene Symbol: CYP11B1
UniProtKB Entry: Q3TG86
Assay organism Assay description Assay tissue Bioactivities Reference

>Cyp11b1|ENSMUSG00000075604
MTMALRVTTDVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILRE QGQENLHLEMHQVFRELGPIFRHSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESWIV HRELRGLGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLE SVHGSFSMDFQSSVFNYTIEASHFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQLL YLPRSLTRWTSTRVWKENLESWDFISEYVTKCIKNVYRELAEGRPQSWSVTAELVAERTL SMDAIQANSMELIAGSTDTTSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAM SDLPLLRAALKETLRLYPVGTFLERILSSDLVLQNYHVPAGTVLNVNLYSMGRNPAVFPR PERYMPQRWLERKRSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVR MAYRFVLMPSSSPLLTFRPVN

Identifier Resolution Method Chain Positions Source
Source Identifier Method Resolution Positions confidence_type Confidence Avg.local score
AlphaFold DB AF-Q3TG86-F1 Predicted 1-501 pLDDT 89.0
Metabolism R-MMU-1430728
Glucocorticoid biosynthesis R-MMU-194002
Metabolism of steroid hormones R-MMU-196071
Biological oxidations R-MMU-211859
Cytochrome P450 - arranged by substrate type R-MMU-211897
Phase I - Functionalization of compounds R-MMU-211945
Endogenous sterols R-MMU-211976
Metabolism of lipids R-MMU-556833
Metabolism of steroids R-MMU-8957322
Expression Atlas ENSMUSG00000075604
MGI Symbol MGI:88583
NCBI gene (formerly Entrezgene) 110115
UniProtKB Gene Name Q3TG86
WikiGene 110115
CYTOCHROME P450, FAMILY 11, SUBFAMILY B, POLYPEPTIDE 2
Ensembl ID : ENSMUSG00000022589
Gene Symbol: CYP11B2
UniProtKB Entry: P15539
Assay organism Assay description Assay tissue Bioactivities Reference

>Cyp11b2|ENSMUSG00000022589
MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQG QENLHLEMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHR ELRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNA RGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTSQLLFL PKSLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAELISQGSLP LDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQKALRQESLAAEASIAANPQKAMS DLPLLRAALKETLRLYPVGGFLERILSSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRP ERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVETLRQEDVQM AYRFVLMPSSSPVLTFRPVS

Identifier Resolution Method Chain Positions Source
Source Identifier Method Resolution Positions confidence_type Confidence Avg.local score
AlphaFold DB AF-P15539-F1 Predicted 1-500 pLDDT 89.44
Metabolism R-MMU-1430728
Mineralocorticoid biosynthesis R-MMU-193993
Glucocorticoid biosynthesis R-MMU-194002
Metabolism of steroid hormones R-MMU-196071
Biological oxidations R-MMU-211859
Cytochrome P450 - arranged by substrate type R-MMU-211897
Phase I - Functionalization of compounds R-MMU-211945
Endogenous sterols R-MMU-211976
Metabolism of lipids R-MMU-556833
Metabolism of steroids R-MMU-8957322
Expression Atlas ENSMUSG00000022589
MGI Symbol MGI:88584
NCBI gene (formerly Entrezgene) 13072
UniProtKB Gene Name P15539
WikiGene 13072
CYTOCHROME P450, FAMILY 4, SUBFAMILY F, POLYPEPTIDE 18
Ensembl ID : ENSMUSG00000003484
Gene Symbol: CYP4F18
UniProtKB Entry: Q99N16
Assay organism Assay description Assay tissue Bioactivities Reference

>Cyp4f18|ENSMUSG00000003484
MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWI LGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPK DTVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQR LASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLL LHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRRTLLDQGGVDVLKAKAKAKTLDFID VLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRE LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVIS RISIFGTHHNPAVWPDPEVYDPFRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKV ALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ

Identifier Resolution Method Chain Positions Source
Source Identifier Method Resolution Positions confidence_type Confidence Avg.local score
AlphaFold DB AF-Q99N16-F1 Predicted 1-524 pLDDT 91.94
Metabolism R-MMU-1430728
Biological oxidations R-MMU-211859
Cytochrome P450 - arranged by substrate type R-MMU-211897
Fatty acids R-MMU-211935
Phase I - Functionalization of compounds R-MMU-211945
Miscellaneous substrates R-MMU-211958
Eicosanoids R-MMU-211979
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-MMU-2142691
Arachidonate metabolism R-MMU-2142753
Metabolism of lipids R-MMU-556833
Fatty acid metabolism R-MMU-8978868
Expression Atlas ENSMUSG00000003484
MGI Symbol MGI:1919304
NCBI gene (formerly Entrezgene) 72054
UniProtKB Gene Name Q99N16
WikiGene 72054
CYTOCHROME P450, FAMILY 8, SUBFAMILY B, POLYPEPTIDE 1
Ensembl ID : ENSMUSG00000050445
Gene Symbol: CYP8B1
UniProtKB Entry: A0A0R4J0N7
Assay organism Assay description Assay tissue Bioactivities Reference

>Cyp8b1|ENSMUSG00000050445
MTLWCTVLGALLTVVGCLCLSLLLRHRRPWEPPLDKGFVPWLGHSMAFRKNMFEFLKGMR AKHGDVFTVQLGGQYFTFVMDPLSFGPIIKNTEKALDFQSYAKELVLKVFGYQSVDGDHR MIHLASTKHLMGQGLEELNQAMLDSLSLVMLGPKGSSLGASSWCEDGLFHFCYRILFKAG FLSLFGYTKDKQQDLDEADELFRKFRRFDFLFPRFVYSLLGPREWVEVSQLQRLFHQRLS VKQNLEKDGISCWLGYMLQFLREQGIASSMQDKFNFMMLWASQGNTGPTCFWVLLFLLKH QDAMKAVREEATRVMGKARLEAKKSFTFTPSALKHTPVLDSVMEESLRLCATPTLLRVVQ EDYVLKMASGQEYQIRRGDKVALFPYLSVHMDPDIHPEPTAFKYDRFLNPDGTRKVDFYK SGKKIHHYSMPWGSGVSKCPGRFFALSEMKTFVLLMIMYFDFKLVDPDIPVPPIDPRRWG FGTSQPSHEVRFLYRLKPVQ

Identifier Resolution Method Chain Positions Source
Source Identifier Method Resolution Positions confidence_type Confidence Avg.local score
AlphaFold DB AF-A0A0R4J0N7-F1 Predicted 1-500 pLDDT 91.12
Metabolism R-MMU-1430728
Synthesis of bile acids and bile salts R-MMU-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-MMU-193368
Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-MMU-193775
Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-MMU-193807
Bile acid and bile salt metabolism R-MMU-194068
Biological oxidations R-MMU-211859
Cytochrome P450 - arranged by substrate type R-MMU-211897
Phase I - Functionalization of compounds R-MMU-211945
Endogenous sterols R-MMU-211976
Eicosanoids R-MMU-211979
Sterols are 12-hydroxylated by CYP8B1 R-MMU-211994
Arachidonate metabolism R-MMU-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-MMU-2162123
Metabolism of lipids R-MMU-556833
Metabolism of steroids R-MMU-8957322
Fatty acid metabolism R-MMU-8978868
Expression Atlas ENSMUSG00000050445
MGI Symbol MGI:1338044
NCBI gene (formerly Entrezgene) 13124
UniProtKB Gene Name A0A0R4J0N7
WikiGene 13124
CYTOCHROME P450, FAMILY 1, SUBFAMILY A, POLYPEPTIDE 2
Ensembl ID : ENSMUSG00000032310
Gene Symbol: CYP1A2
UniProtKB Entry: B6VGH4
Assay organism Assay description Assay tissue Bioactivities Reference
MICONAZOLE
Inhibition of CYP1A2 in mouse liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis Liver IC50 = 4550.0 nM

>Cyp1a2|ENSMUSG00000032310
MAFSQYISLAPELLLATAIFCLVFWMVRASRTQVPKGLKNPPGPWGLPFIGHMLTVGKNP HLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGK SMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASSCYLEEHVSKEANHLVSKLQKAMA EVGHFEPVSQVVESVANVIGAMCFGKNFPRKSEEMLNIVNNSKDFVENVTSGNAVDFFPV LRYLPNPALKRFKTFNDNFVLFLQKTVQEHYQDFNKNSIQDITSALFKHSENYKDNGGLI PEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDR PQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKERCIYINQWQVNHDEKQWK DPFVFRPERFLTNNNSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFS VPPGVKVDLTPNYGLTMKPGTCEHVQAWPRFSK

Identifier Resolution Method Chain Positions Source
Source Identifier Method Resolution Positions confidence_type Confidence Avg.local score
AlphaFold DB AF-B6VGH4-F1 Predicted 1-513 pLDDT 93.38
AlphaFold DB AF-P00186-F1 Predicted 1-513 pLDDT 93.81
Metabolism R-MMU-1430728
Phase II - Conjugation of compounds R-MMU-156580
Methylation R-MMU-156581
Biological oxidations R-MMU-211859
Cytochrome P450 - arranged by substrate type R-MMU-211897
Phase I - Functionalization of compounds R-MMU-211945
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-MMU-211957
Xenobiotics R-MMU-211981
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-MMU-2142670
Arachidonate metabolism R-MMU-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-MMU-2142816
Aflatoxin activation and detoxification R-MMU-5423646
Metabolism of lipids R-MMU-556833
Fatty acid metabolism R-MMU-8978868
Biosynthesis of DHA-derived SPMs R-MMU-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-MMU-9018678
Biosynthesis of protectins R-MMU-9018681
Biosynthesis of maresins R-MMU-9018682
Biosynthesis of maresin-like SPMs R-MMU-9027307
Expression Atlas ENSMUSG00000032310
MGI Symbol MGI:88589
NCBI gene (formerly Entrezgene) 13077
UniProtKB Gene Name P00186
UniProtKB Gene Name P00186
WikiGene 13077