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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Retinoic acid receptor agonist
ROUTE OF ADMINISTRATION: ORAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; OTHER
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Hematologic Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Anemia; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Adenoid Cystic; Cholangitis, Sclerosing; Emphysema; Keratosis, Actinic; Kidney Neoplasms; Lentigo; Lung Neoplasms; Lymphoma; Melanoma; Multiple Myeloma; Neuroblastoma; Pancreatic Neoplasms; Prostatic Neoplasms; Severe Acute Respiratory Syndrome; Small Cell Lung Carcinoma; Striae Distensae; Breast Neoplasms; Carcinoma, Basal Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Rosacea; Acne Vulgaris; Hyperpigmentation; Leukemia, Promyelocytic, Acute; Melanosis; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Breast Neoplasms; Dermatitis, Atopic; Hemorrhoids; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thymidylate synthase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Astrocytoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Gliosarcoma; Neoplasms; Oligodendroglioma; Intracranial Hypertension; Meningitis, Cryptococcal; Candidiasis; Infections; Meningitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Infections; Bacteremia; Gram-Positive Bacterial Infections; Osteomyelitis; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Infections; Acquired Immunodeficiency Syndrome; Meningitis; Tuberculosis, Multidrug-Resistant; Tuberculosis; Tuberculosis, Pulmonary
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hepatitis C; Intestinal Obstruction; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Feeding and Eating Disorders; Hypogonadism; Irritable Bowel Syndrome; Neuralgia; Obesity; Pruritus; Chronic Pain; Epilepsy; Heroin Dependence; Low Back Pain; Morphine Dependence; Mycosis Fungoides; Neoplasms; Opioid-Related Disorders; Osteoarthritis; Pain; Parkinson Disease; Restless Legs Syndrome; Sezary Syndrome; Substance Withdrawal Syndrome; Substance-Related Disorders; Constipation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alcoholism; Autistic Disorder; Brain Injuries; Carcinoma, Non-Small-Cell Lung; Cerebral Hemorrhage; Child Development Disorders, Pervasive; Cholangitis, Sclerosing; Fibromyalgia; Glioblastoma; Glioma; Hemorrhage; Macular Edema; Memory Disorders; Periapical Periodontitis; Pneumonia; Retinal Vein Occlusion; Skin Diseases; Angelman Syndrome; Asthma; Atrial Fibrillation; Carotid Stenosis; Chronic Pain; Colorectal Neoplasms; Cystic Fibrosis; Depressive Disorder, Major; Esophageal Neoplasms; Fragile X Syndrome; HIV Infections; Head and Neck Neoplasms; Huntington Disease; Impetigo; Lung Neoplasms; Macular Degeneration; Multiple Myeloma; Multiple Sclerosis, Relapsing-Remitting; Neuralgia; Obsessive-Compulsive Disorder; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Parkinson Disease; Retinal Detachment; Retinitis Pigmentosa; Stroke; Amyotrophic Lateral Sclerosis; Arthritis, Rheumatoid; Bipolar Disorder; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Heroin Dependence; Hypertension; Idiopathic Pulmonary Fibrosis; Lichen Planus, Oral; Multiple Sclerosis; Neurobehavioral Manifestations; Peri-Implantitis; Periodontitis; Pneumothorax; Psychotic Disorders; Rosacea; Schizophrenia; Spinal Cord Injuries; Acne Vulgaris; Bacterial Infections; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperemia; Neoplasms; Common Cold; Conjunctivitis, Allergic; Influenza, Human; Eye Manifestations; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Postoperative Nausea and Vomiting; Vertigo; Hypersensitivity; Vomiting
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Muscarinic acetylcholine receptor M3 agonist
ROUTE OF ADMINISTRATION: INTRAOCULAR
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Presbyopia; Cataract; Glaucoma; Miosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: BUCCAL; IMPLANTATION; INJECTION; NASAL; TRANSDERMAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Aging; Kallmann Syndrome; Penile Induration; Acquired Immunodeficiency Syndrome; Anorexia Nervosa; Dwarfism; Heart Failure; Hereditary Breast and Ovarian Cancer Syndrome; Menopause; Multiple Sclerosis; Muscular Diseases; Obesity; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcopenia; Spinal Cord Injuries; Testicular Neoplasms; Coronary Disease; Disorders of Sex Development; Erectile Dysfunction; Hip Fractures; Infertility; Metabolic Syndrome; Neoplasms; Renal Insufficiency, Chronic; Sexual Dysfunction, Physiological; Hypogonadism; Klinefelter Syndrome; Orchitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; OTHER
THERAPEUTIC INDICATION: Dermatitis, Atopic; Eye Diseases; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel protein type IV alpha subunit blocker
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: EMERGENCY MEDICINE; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Aortic Coarctation; Brain Neoplasms; HIV Infections; Prostatic Neoplasms, Castration-Resistant; Sinusitis; Vasospasm, Intracranial; Abdominal Pain; Appendicitis; Atrial Fibrillation; Blepharoptosis; Blood Coagulation Disorders; Cleft Palate; Dupuytren Contracture; Fasciitis, Plantar; Femoral Neck Fractures; Headache; Hemorrhage; Hernia, Umbilical; Hip Fractures; Hypospadias; Hypotension; Lacrimal Apparatus Diseases; Low Back Pain; Lung Neoplasms; Mucositis; Musculoskeletal Diseases; Osteoarthritis, Hip; Osteoarthritis, Knee; Pregnancy; Pulpitis; Rib Fractures; Rotator Cuff Injuries; Sarcoma; Shoulder Pain; Spinal Stenosis; Ankle Fractures; Breast Neoplasms; Breech Presentation; Carcinoma, Non-Small-Cell Lung; Chronic Pain; Cough; Fractures, Bone; Genital Neoplasms, Female; Hallux Valgus; Hemorrhoids; Hernia, Inguinal; Ileus; Liver Diseases; Migraine Disorders; Neoplasms; Osteoarthritis; Pancreatic Neoplasms; Pancreatitis, Chronic; Peritoneal Neoplasms; Postoperative Complications; Postoperative Nausea and Vomiting; Radiculopathy; Toothache; Urethral Stricture; Wounds and Injuries; Hernia; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D2 receptor antagonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Psoriasis; Psychotic Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Corneal Opacity; Dry Eye Syndromes; Acne Vulgaris; Eye Diseases; Hemorrhoids; Inflammation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive modulator
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor alpha agonist
ROUTE OF ADMINISTRATION: INJECTION; ORAL; VAGINAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Prostatic Neoplasms, Castration-Resistant; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Potassium channel, inwardly rectifying, subfamily J, member 11 opener
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Depressive Disorder; Diabetes Mellitus, Type 2; Obesity; Adenoma, Islet Cell; Hyperinsulinism; Hypertension; Hypoglycemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Toxemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Keratitis, Herpetic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Tuberculosis, Multidrug-Resistant; Tuberculosis; Bacterial Infections; Eye Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Monoamine transporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Narcolepsy; Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Adenoma; Carcinoma, Renal Cell; Colorectal Neoplasms; Hashimoto Disease; Lung Neoplasms; Lymphoma, Follicular; Prostatic Neoplasms, Castration-Resistant
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: BUCCAL; ORAL; SUBLINGUAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Menopause; Breast Neoplasms; Hypogonadism; Orchitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Neoplasms; Seminoma; Testicular Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bile acids sequestering agent
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Rhinitis, Allergic, Seasonal
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial dihydrofolate reductase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Anemia; Astrocytoma; Brain Neoplasms; Glioblastoma; Granulomatosis with Polyangiitis; Kidney Diseases; Leber Congenital Amaurosis; Leukemia, Biphenotypic, Acute; Neoplasms; Pulmonary Disease, Chronic Obstructive; Cystic Fibrosis; Dermatitis, Atopic; Diabetes Mellitus, Type 1; Eczema; Epidermolysis Bullosa; Lymphoma, AIDS-Related; Abscess; Bacteremia; HIV Infections; Idiopathic Pulmonary Fibrosis; Malaria; Measles; Pneumonia; Pyelonephritis; Sepsis; Staphylococcal Infections; Toxoplasmosis, Ocular; Tuberculosis; Bacterial Infections; Infections; Otitis Media; Pneumonia, Pneumocystis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Melanoma; Fractures, Bone; Arrhythmias, Cardiac; Bacteremia; Cellulitis; Gram-Positive Bacterial Infections; Infections; Laryngeal Neoplasms; Osteomyelitis; Prostatic Neoplasms, Castration-Resistant; Skin Diseases; Staphylococcal Infections; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Heart Diseases; Substance-Related Disorders; Brain Injuries; Status Epilepticus; Sleep Initiation and Maintenance Disorders