EcoDrugPlus


Trade Names	ORINASE TOLBUTAMIDE
Synonyms	1-butyl-3-(p-tolylsulfonyl)urea Arkozal Butamide Diabetamid Glyconon Ipoglicone NSC-23813 NSC-87833 Orinase Pramidex Rastinon Tolbutamide Tolbutamidum Willbutamide
Status
Molecule Category	Free-form
ATC	A10BB03 V04CA01
UNII	982XCM1FOI
EPA CompTox	DTXSID8021359

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	JLRGJRBPOGGCBT-UHFFFAOYSA-N
Smiles	CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1
InChI	InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C12H18N2O3S
Molecular Weight	270.35
AlogP	1.78
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	75.27
Molecular species	ACID
Aromatic Rings	1.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Sulfonylurea receptor 1, Kir6.2 blocker	BLOCKER	PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9	-	-	-	-	87.68
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	5.8-125.25

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	99.86-125.25
Homo sapiens	-	-	-	-	5.8-87.68
Mus musculus	-	-	-	-	45-47.23
Rattus norvegicus	-	-	-	-	16-48

Target Conservation


Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-binding cassette sub-family C member 8 Organism : Homo sapiens Q09428 ENSG00000006071












Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-sensitive inward rectifier potassium channel 11 Organism : Homo sapiens Q14654 ENSG00000187486

Cross References

Resources	Reference
CAS NUMBER	64-77-7
ChEBI	27999
ChEMBL	CHEMBL782
DrugBank	DB01124
DrugCentral	2696
FDA SRS	982XCM1FOI
Human Metabolome Database	HMDB0015256
Guide to Pharmacology	6848
KEGG	C07148
PharmGKB	PA451718
PubChem	5505
SureChEMBL	SCHEMBL15918
ZINC	ZINC000001530703

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026

TOLBUTAMIDE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References