CHLORMEZANONE

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Search structure


Trade Names	TRANCOPAL
Synonyms	Chlormethazanone Chlormezanone Lyseen new NSC-169108 Trancopal
Status
Molecule Category	Free-form
ATC	M03BB02
UNII	GP568V9G19
EPA CompTox	DTXSID3022798

Structure


InChI Key	WEQAYVWKMWHEJO-UHFFFAOYSA-N
Smiles	CN1C(=O)CCS(=O)(=O)C1c1ccc(Cl)cc1
InChI	InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C11H12ClNO3S
Molecular Weight	273.74
AlogP	1.62
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	1.0
Polar Surface Area	54.45
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	92-97.47

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	92-97.47

Cross References

Resources	Reference
CAS NUMBER	80-77-3
ChEBI	3619
ChEMBL	CHEMBL1200714
DrugBank	DB01178
DrugCentral	603
FDA SRS	GP568V9G19
Human Metabolome Database	HMDB0015309
Guide to Pharmacology	7323
PharmGKB	PA448939
PubChem	2717
SureChEMBL	SCHEMBL217864

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026