TRICHLORMETHIAZIDE


Trade Names	METAHYDRIN NAQUA TRICHLOREX TRICHLORMAS TRICHLORMETHIAZIDE
Synonyms	Metahydrin NSC-61560 Naqua Trichlorex Trichlormas Trichlormethiazide Trichloromethiazide
Status
Molecule Category	Free-form
ATC	C03AA06
UNII	Q58C92TUN0
EPA CompTox	DTXSID7023699


InChI Key	LMJSLTNSBFUCMU-UHFFFAOYSA-N
Smiles	NS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O
InChI	InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

Property Name	Value
Molecular Formula	C8H8Cl3N3O4S2
Molecular Weight	380.66
AlogP	0.82
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	118.36
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	20.0

Mechanism of Action	Action	Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor	INHIBITOR	DOI

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Lyase	-	-	-	7.9-763	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	81.82-86.79

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	81.82-86.79
Homo sapiens	-	-	-	7.9-763	-
Mus musculus	-	-	-	645	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	9683
ChEMBL	CHEMBL1054
DrugBank	DB01021
DrugCentral	2733
FDA SRS	Q58C92TUN0
Human Metabolome Database	HMDB0015156
Guide to Pharmacology	7314
KEGG	C07767
PDB	TRU
PharmGKB	PA164752426
PubChem	5560
SureChEMBL	SCHEMBL25492
ZINC	ZINC00897236

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

TRICHLORMETHIAZIDE

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Physicochemical Descriptors

Pharmacology

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