EcoDrugPlus


Trade Names	RENESE
Synonyms	NSC-108161 Nephril P-2525 Polythiazide Renese
Status
Molecule Category	Free-form
ATC	C03AA05
UNII	SWY93BD8RL
EPA CompTox	DTXSID6025939


InChI Key	CYLWJCABXYDINA-UHFFFAOYSA-N
Smiles	CN1C(CSCC(F)(F)F)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O
InChI	InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)

Property Name	Value
Molecular Formula	C11H13ClF3N3O4S3
Molecular Weight	439.89
AlogP	1.66
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	109.57
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	25.0

Mechanism of Action	Action	Reference
Thiazide-sensitive sodium-chloride cotransporter inhibitor	INHIBITOR	DOI DailyMed Wikipedia

Resources	Reference
ChEBI	8327
ChEMBL	CHEMBL1587
DrugBank	DB01324
DrugCentral	2228
FDA SRS	SWY93BD8RL
Human Metabolome Database	HMDB0015419
Guide to Pharmacology	7274
KEGG	C07766
PharmGKB	PA164748763
PubChem	4870
SureChEMBL	SCHEMBL27909

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

POLYTHIAZIDE

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References