TAZOBACTAM SODIUM

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Synonyms
Status
Molecule Category Salt-form
UNII UXA545ABTT
EPA CompTox DTXSID8046030
Parent Compound: TAZOBACTAM

Structure

InChI Key RFMIKMMOLPNEDG-QVUDESDKSA-M
Smiles C[C@]1(Cn2ccnn2)[C@H](C(=O)[O-])N2C(=O)C[C@H]2S1(=O)=O.[Na+]
InChI
InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H11N4NaO5S
Molecular Weight 322.28
AlogP -1.52
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 122.46
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 20.0

Pharmacology

Mechanism of Action Action Reference
Bacterial beta-lactamase TEM inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 25-943 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enterobacter cloacae
- 320-943 - - -
Escherichia coli
- 25-100 - - -
Staphylococcus aureus
- 290-297 - - -

Cross References

Resources Reference
ChEBI 85192
ChEMBL CHEMBL1439
FDA SRS UXA545ABTT
PubChem 23663400
SureChEMBL SCHEMBL259991
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