TAZOBACTAM

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Synonyms
Status
Molecule Category Free-form
ATC J01CG02
UNII SE10G96M8W
EPA CompTox DTXSID8023634

Structure

InChI Key LPQZKKCYTLCDGQ-WEDXCCLWSA-N
Smiles C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
InChI
InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C10H12N4O5S
Molecular Weight 300.3
AlogP -1.52
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 122.46
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 20.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 2-943 - 190 -
Enzyme
- 2-943 - 190 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Bacillus clausii
- 4 - - -
Bacillus licheniformis
- 510 - - -
Bacteria
- 1-730 - 190-200 -
Brachyspira pilosicoli
- 160 - - -
Burkholderia cenocepacia
- 500 - - -
Carnobacterium divergens
- 270 - - -
Citrobacter freundii
- 96-930 - - -
Citrobacter gillenii
- 40 - - -
Enterobacter cloacae
- 30-943 - - -
Escherichia coli
- 2-400 - 0.4-900 -
Klebsiella pneumoniae
- 80-374 - - -
Morganella morganii
- 190 - - -
Pseudomonas aeruginosa
- 60-820 - - -
Pseudomonas aeruginosa PAO1
- 844.4 - - -
Pseudomonas luteola
- 40 - - -
Salmonella enterica subsp. enterica serovar Westhampton
- 2.2 - - -
Staphylococcus aureus
- 500 - - -

Related Entries

Cross References

Resources Reference
ChEBI 9421
ChEMBL CHEMBL404
DrugBank DB01606
DrugCentral 2572
FDA SRS SE10G96M8W
Human Metabolome Database HMDB0015544
Guide to Pharmacology 10789
KEGG C07771
PharmGKB PA164764504
PubChem 123630
SureChEMBL SCHEMBL122302
ZINC ZINC000003787060
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