None is not found in the database.

ZIPRASIDONE HYDROCHLORIDE

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Search structure


Trade Names	GEODON ZIPRASIDONE HYDROCHLORIDE
Synonyms	CP-88,059-1 CP-88059-1 CP-880591 Geodon Zeldox Ziprasidone hydrochloride Ziprasidone hydrochloride hydrate Ziprasidone hydrochloride monohydrate
Status
Molecule Category	Salt-form
UNII	216X081ORU
EPA CompTox	DTXSID00160855
Parent Compound:	ZIPRASIDONE

Structure


InChI Key	ZCBZSCBNOOIHFP-UHFFFAOYSA-N
Smiles	Cl.O.O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
InChI	InChI=1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H24Cl2N4O2S
Molecular Weight	467.42
AlogP	3.81
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	48.47
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	DailyMed

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295












Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246

Cross References

Resources	Reference
ChEBI	32314
ChEMBL	CHEMBL1375743
FDA SRS	216X081ORU
Guide to Pharmacology	59
KEGG	C07568
PubChem	60853
SureChEMBL	SCHEMBL122875
ZINC	ZINC00538550

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025