None is not found in the database.

ZIPRASIDONE

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Search structure


Synonyms	CP-88059 Geodon Zipradon Ziprasidone
Status
Molecule Category	Free-form
ATC	N05AE04
UNII	6UKA5VEJ6X
EPA CompTox	DTXSID4023753

Structure


InChI Key	MVWVFYHBGMAFLY-UHFFFAOYSA-N
Smiles	O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1
InChI	InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H21ClN4OS
Molecular Weight	412.95
AlogP	3.81
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	48.47
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-
Ion channel Ligand-gated ion channel 5HT3 receptor	-	-	-	398.11	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	120.23-152	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	11	-	0.5-501.19	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	5	-	0.42-330	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	150	-	5.3-510	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	0.42	-	0.08-76	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	-	-	48-79.43	-
Transporter Electrochemical transporter	-	-	-	48-79.43	86.6
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	-	-	-	19

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	15.85	-
Homo sapiens	-	0.42-152	-	0.08-398.11	-5.07-19
Rattus norvegicus	-	150	-	0.4169-501.19	-
Staphylococcus aureus	-	-	-	-	86.6

Cross References

Resources	Reference
ChEBI	10119
ChEMBL	CHEMBL708
DrugBank	DB00246
DrugCentral	2865
FDA SRS	6UKA5VEJ6X
Human Metabolome Database	HMDB0014391
Guide to Pharmacology	59
KEGG	C07568
PharmGKB	PA451974
PubChem	60854
SureChEMBL	SCHEMBL28028
ZINC	ZINC000000538550

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025