TRIHEXYPHENIDYL HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII AO61G82577
EPA CompTox DTXSID8045802
Parent Compound: TRIHEXYPHENIDYL

Structure

InChI Key QDWJJTJNXAKQKD-UHFFFAOYSA-N
Smiles Cl.OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1
InChI
InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H32ClNO
Molecular Weight 337.94
AlogP 4.33
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 23.47
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 22.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action Action Reference
Muscarinic acetylcholine receptor M1 antagonist ANTAGONIST ISBN PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 1.3-26.3 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 73.95-83.05
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 73.95-83.05

Target Conservation

Protein: Muscarinic acetylcholine receptor M1
Description: Muscarinic acetylcholine receptor M1
Organism : Homo sapiens
P11229 ENSG00000168539

Cross References

Resources Reference
ChEBI 9721
ChEMBL CHEMBL1092
FDA SRS AO61G82577
Guide to Pharmacology 7315
KEGG C07171
PubChem 66007
SureChEMBL SCHEMBL42410
ZINC ZINC00968274
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