TRIFLUPROMAZINE HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 9E75N4A5HM
EPA CompTox DTXSID8045804
Parent Compound: TRIFLUPROMAZINE

Structure

InChI Key FTNWXGFYRHWUKG-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl
InChI
InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H20ClF3N2S
Molecular Weight 388.89
AlogP 5.26
Hydrogen Bond Acceptor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Dopamine D2 receptor antagonist ANTAGONIST KEGG Other PubMed PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 83.79-185.58
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 83.79-185.58

Target Conservation

Protein: Dopamine D2 receptor
Description: D(2) dopamine receptor
Organism : Homo sapiens
P14416 ENSG00000149295

Cross References

Resources Reference
ChEBI 9712
ChEMBL CHEMBL1201102
FDA SRS 9E75N4A5HM
Guide to Pharmacology 4330
KEGG D00390
PubChem 66069
SureChEMBL SCHEMBL317144
ZINC ZINC00538507
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