TRIFLUPROMAZINE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC N05AA05
UNII RO16TQF95Y
EPA CompTox DTXSID9023704

Structure

InChI Key XSCGXQMFQXDFCW-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21
InChI
InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H19F3N2S
Molecular Weight 352.43
AlogP 5.26
Hydrogen Bond Acceptor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Dopamine D2 receptor antagonist ANTAGONIST KEGG Other PubMed PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 45
Enzyme Oxidoreductase
- - - - 12.35
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Bos taurus
- - - - 45
Homo sapiens
- - - - 12.35

Target Conservation

Protein: Dopamine D2 receptor
Description: D(2) dopamine receptor
Organism : Homo sapiens
P14416 ENSG00000149295

Related Entries

Cross References

Resources Reference
ChEBI 9711
ChEMBL CHEMBL570
DrugBank DB00508
DrugCentral 2742
FDA SRS RO16TQF95Y
Human Metabolome Database HMDB0014650
Guide to Pharmacology 4330
PharmGKB PA451773
PubChem 5568
SureChEMBL SCHEMBL44085
ZINC ZINC000000538507
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