NAPHAZOLINE HYDROCHLORIDE


Trade Names	ALBALON NAFAZAIR NAPHAZOLINE HYDROCHLORIDE NAPHCON FORTE OPCON VASOCON
Synonyms	Albalon Antistin-privine Gppe nsl soln NSC-35711 Nafazair Naphaz hcl Naphazoline HCl Naphazoline hcl Naphazoline hydrochloride Naphazoline nitrate Naphcon Naphcon forte Opcon Vasocon
Status
Molecule Category	Salt-form
UNII	MZ1131787D
EPA CompTox	DTXSID7045788
Parent Compound:	NAPHAZOLINE


InChI Key	DJDFFEBSKJCGHC-UHFFFAOYSA-N
Smiles	Cl.c1ccc2c(CC3=NCCN3)cccc2c1
InChI	InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

Mechanism of Action	Action	Reference
Adrenergic receptor alpha agonist	AGONIST	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	12	0.0011	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	95.85-100.66

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	95.85-100.66


Protein: Adrenergic receptor alpha Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286











Protein: Adrenergic receptor alpha Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160









Protein: Adrenergic receptor alpha Description: Alpha-1D adrenergic receptor Organism : Homo sapiens P25100 ENSG00000171873











Protein: Adrenergic receptor alpha Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907











Protein: Adrenergic receptor alpha Description: Alpha-1B adrenergic receptor Organism : Homo sapiens P35368 ENSG00000170214

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