NAPHAZOLINE


Synonyms	Nafazair Nafazolin Naphazoline
Status
Molecule Category	Free-form
ATC	R01AA08 R01AB02 S01GA01
UNII	H231GF11BV
EPA CompTox	DTXSID3048449


InChI Key	CNIIGCLFLJGOGP-UHFFFAOYSA-N
Smiles	c1ccc2c(CC3=NCCN3)cccc2c1
InChI	InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)

Property Name	Value
Molecular Formula	C14H14N2
Molecular Weight	210.28
AlogP	2.38
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	24.39
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	16.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	54.95-63.1	4.8-410	-	2.291-5.7	-
Other cytosolic protein	-	-	-	121.6-245.47	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	54.95	-	-	2.291-147.1	-
Rattus norvegicus	-	-	-	5.7-245.47	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	93363
ChEMBL	CHEMBL761
DrugBank	DB06711
DrugCentral	3369
FDA SRS	H231GF11BV
Human Metabolome Database	HMDB0015656
Guide to Pharmacology	5509
PharmGKB	PA165958384
PubChem	4436
SureChEMBL	SCHEMBL34532
ZINC	ZINC000000119717

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

NAPHAZOLINE

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Physicochemical Descriptors

Pharmacology

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