MECLIZINE HYDROCHLORIDE

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Search structure


Trade Names	ANTIVERT MECLIZINE HYDROCHLORIDE
Synonyms	Agyrax Ancolan Ancoloxin Antivert Bonamine Meclizine dihydrochloride monohydrate Meclizine hcl Meclizine hydrochloride Meclizine monohydrochloride Meclozine dihydrochloride Meclozine hydrochloride Meclozine hydrochloride monohydrate Meclozine monohydrochloride NSC-28728 NSC-757094
Status
Molecule Category	Salt-form
UNII	HDP7W44CIO
Parent Compound:	MECLIZINE

Structure


InChI Key	KDLHYOMCWBWLMM-UHFFFAOYSA-N
Smiles	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl.Cl.O
InChI	InChI=1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H31Cl3N2O
Molecular Weight	481.9
AlogP	5.56
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	6.48
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed DailyMed

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	31805
ChEMBL	CHEMBL3989555
FDA SRS	HDP7W44CIO
Guide to Pharmacology	2757
KEGG	C07116
PubChem	173612
SureChEMBL	SCHEMBL743004
ZINC	ZINC19594557

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025