EcoDrugPlus


Synonyms	Meclizine Meclozine NSC-169189
Status
Molecule Category	Free-form
UNII	3L5TQ84570
EPA CompTox	DTXSID0023242


InChI Key	OCJYIGYOJCODJL-UHFFFAOYSA-N
Smiles	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1
InChI	InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3

Property Name	Value
Molecular Formula	C25H27ClN2
Molecular Weight	390.96
AlogP	5.56
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	6.48
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	28.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	16.4

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	16.4

Resources	Reference
ChEBI	6709
ChEMBL	CHEMBL1623
DrugBank	DB00737
DrugCentral	1649
FDA SRS	3L5TQ84570
Human Metabolome Database	HMDB0014875
Guide to Pharmacology	2757
KEGG	C07116
PharmGKB	PA450338
PubChem	4034
SureChEMBL	SCHEMBL4649

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MECLIZINE

Structure

Physicochemical Descriptors

Pharmacology

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