IMIPRAMINE HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII BKE5Q1J60U
EPA CompTox DTXSID7040738
Parent Compound: IMIPRAMINE

Structure

InChI Key XZZXIYZZBJDEEP-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
InChI
InChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H25ClN2
Molecular Weight 316.88
AlogP 3.88
Hydrogen Bond Acceptor 2.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Mechanism of Action Action Reference
Norepinephrine transporter inhibitor INHIBITOR DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 2.6 - 12-41.8 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 61.55-92.77
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 61.55-92.77
Mus musculus
- - - - 28
Rattus norvegicus
- - - 12 -

Target Conservation

Protein: Norepinephrine transporter
Description: Sodium-dependent noradrenaline transporter
Organism : Homo sapiens
P23975 ENSG00000103546
Protein: Serotonin transporter
Description: Sodium-dependent serotonin transporter
Organism : Homo sapiens
P31645 ENSG00000108576

Cross References

Resources Reference
ChEBI 5882
ChEMBL CHEMBL1692
FDA SRS BKE5Q1J60U
Guide to Pharmacology 357
KEGG C07982
PDB IXX
PubChem 8228
SureChEMBL SCHEMBL41765
ZINC ZINC00020245
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