IMIPRAMINE

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC N06AA02
UNII OGG85SX4E4
EPA CompTox DTXSID1043881

Structure

InChI Key BCGWQEUPMDMJNV-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2CCc2ccccc21
InChI
InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H24N2
Molecular Weight 280.42
AlogP 3.88
Hydrogen Bond Acceptor 2.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel 5HT3 receptor
- 44 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 72.7
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 269-300 - 65 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 1.7-160 - 46-255 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 410-645 - 726-726 63
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- 0.06-27 - 10 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 44-220 - 23-160 15
Membrane receptor
- 0.06-27 - 23-160 15
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 0.88-810 - 0.52-42 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - -2.4-26.9
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 600 - - 82.8
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cavia porcellus
- - 1.259 160-160 72.7
Homo sapiens
- 0.88-600 - 0.52-31 -2.4-82.8
Mus musculus
300 - - - 50-100
Rattus norvegicus
- 27-810 - 12-343 15-68

Related Entries

Environmental Exposure

Environmental Exposure Map
Countries
Germany

Cross References

Resources Reference
ChEBI 47499
ChEMBL CHEMBL11
DrugBank DB00458
DrugCentral 1427
FDA SRS OGG85SX4E4
Human Metabolome Database HMDB0001848
Guide to Pharmacology 357
KEGG C07049
PDB IXX
PharmGKB PA449969
PubChem 3696
SureChEMBL SCHEMBL34282
ZINC ZINC000000020245
CONTENTS