FLUPHENAZINE HYDROCHLORIDE

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Search structure


Trade Names	FLUPHENAZINE HCL FLUPHENAZINE HYDROCHLORIDE PERMITIL PROLIXIN
Synonyms	Fluphenazine dihydrochloride Fluphenazine hydrochloride Moditen NSC-179197 Permitil Prolixin SQUIBB 4918
Status
Molecule Category	Salt-form
UNII	ZOU145W1XL
EPA CompTox	DTXSID00892922
Parent Compound:	FLUPHENAZINE

Structure


InChI Key	MBHNWCYEGXQEIT-UHFFFAOYSA-N
Smiles	Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChI	InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H28Cl2F3N3OS
Molecular Weight	510.45
AlogP	4.31
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	29.95
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	30.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor antagonist	ANTAGONIST	PubMed PubMed PubMed Wikipedia

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295

Cross References

Resources	Reference
ChEBI	5126
ChEMBL	CHEMBL1448187
FDA SRS	ZOU145W1XL
Guide to Pharmacology	204
KEGG	C07010
PubChem	67356
SureChEMBL	SCHEMBL41634
ZINC	ZINC19203912

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025