EcoDrugPlus


Synonyms	Fluphenazine NSC-62323 Permitil Prolixin
Status
Molecule Category	Free-form
ATC	N05AB02
UNII	S79426A41Z
EPA CompTox	DTXSID2023068


InChI Key	PLDUPXSUYLZYBN-UHFFFAOYSA-N
Smiles	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChI	InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2

Property Name	Value
Molecular Formula	C22H26F3N3OS
Molecular Weight	437.53
AlogP	4.31
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	29.95
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	30.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Lyase	-	80	-	-	-
Enzyme	-	80	-	-	-
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	72.8
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	-	-	-	1.44-179	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	-	-	40	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	-	-	800	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	61.9
Transporter Electrochemical transporter	-	-	-	-	61.9

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	72.8
Homo sapiens	-	-	-	1.44-179	61.9
Plasmodium falciparum K1	-	500	-	-	-
Rattus norvegicus	-	500	-	800	-
Staphylococcus aureus	-	-	-	-	75

Resources	Reference
ChEBI	5123
ChEMBL	CHEMBL726
DrugBank	DB00623
DrugCentral	1212
FDA SRS	S79426A41Z
Human Metabolome Database	HMDB0014761
Guide to Pharmacology	204
KEGG	C07010
PharmGKB	PA449676
PubChem	3372
SureChEMBL	SCHEMBL19221
ZINC	ZINC000019203912

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FLUPHENAZINE

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Pharmacology

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