CHLORPROMAZINE HYDROCHLORIDE

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 9WP59609J6
EPA CompTox DTXSID7024827
Parent Compound: CHLORPROMAZINE

Structure

InChI Key FBSMERQALIEGJT-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21.Cl
InChI
InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H20Cl2N2S
Molecular Weight 355.33
AlogP 4.89
Hydrogen Bond Acceptor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 21.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action Action Reference
D2-like dopamine receptor antagonist ANTAGONIST ISBN PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - 3 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 673 -

Target Conservation

Protein: Serotonin 2a (5-HT2a) receptor
Description: 5-hydroxytryptamine receptor 2A
Organism : Homo sapiens
P28223 ENSG00000102468

Cross References

Resources Reference
ChEBI 3649
ChEMBL CHEMBL1713
FDA SRS 9WP59609J6
Guide to Pharmacology 83
KEGG C07952
PDB Z80
PubChem 6240
SureChEMBL SCHEMBL41771
ZINC ZINC00044027
CONTENTS