CHLORPROMAZINE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC N05AA01
UNII U42B7VYA4P
EPA CompTox DTXSID0022808

Structure

InChI Key ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Smiles CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21
InChI
InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H19ClN2S
Molecular Weight 318.87
AlogP 4.89
Hydrogen Bond Acceptor 3.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 21.0

Metabolites Network

visNetwork

Pharmacology

Mechanism of Action Action Reference
D2-like dopamine receptor antagonist ANTAGONIST ISBN PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Lyase
- - - 118 -
Enzyme Oxidoreductase
- 570 - 620 70
Enzyme
- 570 - 118 70
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
- 600 - - 25
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
- - - - 7.15
Ion channel Voltage-gated ion channel Transient receptor potential channel
- - - 520 -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 72.2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - 60.26-158.49 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 31-31 - 1.585-501.19 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 1-112 - 1.2-172 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- 12 - 4.25-50.12 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 3.4-372 - 0.7-673 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 120 - 63.1 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 4.3-99.49
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- - - - 85.1
Transporter Electrochemical transporter
- 120 - 63.1 4.3-99.49
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- - - 600 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Bos taurus
- 34-34 - 10-12 -
Canis lupus familiaris
- - - - 22.2
Cavia porcellus
- 180-600 - 50.12-860 72.2
Cricetulus griseus
- - - - 97.66-99.49
Homo sapiens
- 1-570 640 1.2-620 4.3-85.1
Mus musculus
- - - - 0-304
Plasmodium yoelii
- - - - 85-100
Rattus norvegicus
- 2.15-180 184 1.585-520 -
Saimiri sciureus
- - - - 11-54
Staphylococcus aureus
- - - - 76-81
Sus scrofa
- - - 2.67-8 -
Torpedo nobiliana
- - - - 7.15
Trypanosoma cruzi
- - - - 70

Target Conservation

Protein: Serotonin 2a (5-HT2a) receptor
Description: 5-hydroxytryptamine receptor 2A
Organism : Homo sapiens
P28223 ENSG00000102468

Related Entries

Environmental Exposure

Environmental Exposure Map
Countries
Hungary
Serbia

Cross References

Resources Reference
ChEBI 3647
ChEMBL CHEMBL71
DrugBank DB00477
DrugCentral 621
FDA SRS U42B7VYA4P
Human Metabolome Database HMDB0014620
Guide to Pharmacology 83
KEGG C06906
PDB Z80
PharmGKB PA448964
PubChem 2726
SureChEMBL SCHEMBL8321
ZINC ZINC000000044027
CONTENTS