EcoDrugPlus


Trade Names	FIRDAPSE
Synonyms	3,4-DAPP Amifampridine phosphate DAPP Firdapse Zenas
Status
Molecule Category	Salt-form
UNII	8HF8FIN815
EPA CompTox	DTXSID40196254
Parent Compound:	AMIFAMPRIDINE

Trade Names

FIRDAPSE

Synonyms

3,4-DAPP

Amifampridine phosphate

DAPP

Firdapse

Zenas

Status

Molecule Category

Salt-form

UNII

8HF8FIN815

EPA CompTox

DTXSID40196254

Parent Compound:

AMIFAMPRIDINE


InChI Key	KAICRBBQCRKMPO-UHFFFAOYSA-N
Smiles	Nc1ccncc1N.O=P(O)(O)O
InChI	InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)

InChI Key

KAICRBBQCRKMPO-UHFFFAOYSA-N

Smiles

Nc1ccncc1N.O=P(O)(O)O

InChI

InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)

Property Name	Value
Molecular Formula	C5H10N3O4P
Molecular Weight	207.13
AlogP	0.25
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	2.0
Polar Surface Area	64.93
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	8.0

Property Name

Value

Molecular Formula

C5H10N3O4P

Molecular Weight

207.13

AlogP

0.25

Hydrogen Bond Acceptor

3.0

Hydrogen Bond Donor

2.0

Polar Surface Area

64.93

Molecular species

BASE

Aromatic Rings

1.0

Heavy Atoms

8.0

Mechanism of Action	Action	Reference
Voltage-gated potassium channel blocker	BLOCKER	FDA Other

Mechanism of Action

Action

Reference

Voltage-gated potassium channel blocker

BLOCKER

FDA Other

Resources	Reference
ChEMBL	CHEMBL3301611
FDA SRS	8HF8FIN815
PubChem	9920716
SureChEMBL	SCHEMBL3958357

Resources

Reference

ChEMBL

FDA SRS

PubChem

SureChEMBL

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

AMIFAMPRIDINE PHOSPHATE

Structure

Physicochemical Descriptors

Pharmacology

Cross References