ALFUZOSIN HYDROCHLORIDE

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Search structure


Trade Names	ALFUZOSIN HYDROCHLORIDE UROXATRAL
Synonyms	Alfutral sr Alfuzosin hcl Alfuzosin hydrochloride Benestan Benestan ret Besavar xl Fuzatal xl Kelanu xl SL 77 499-10 SL-77-499-10 SL-77499-10 Urion s Uroxatral Vasran xl Xatral
Status
Molecule Category	Salt-form
UNII	75046A1XTN
EPA CompTox	DTXSID3045514
Parent Compound:	ALFUZOSIN

Structure


InChI Key	YTNKWDJILNVLGX-UHFFFAOYSA-N
Smiles	COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC.Cl
InChI	InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H28ClN5O4
Molecular Weight	425.92
AlogP	1.35
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	8.0
Polar Surface Area	111.83
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-1 agonist	AGONIST	DailyMed

Target Conservation


Protein: Adrenergic receptor alpha-1 Description: Alpha-1D adrenergic receptor Organism : Homo sapiens P25100 ENSG00000171873











Protein: Adrenergic receptor alpha-1 Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907











Protein: Adrenergic receptor alpha-1 Description: Alpha-1B adrenergic receptor Organism : Homo sapiens P35368 ENSG00000170214

Cross References

Resources	Reference
ChEBI	32286
ChEMBL	CHEMBL1723
FDA SRS	75046A1XTN
Guide to Pharmacology	7109
KEGG	D07124
PubChem	71764
SureChEMBL	SCHEMBL179910
ZINC	ZINC01843099

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025