TYLOPHORINE(1R)-7,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-1-SULFONIC ACID SALT


Source	Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	XYDRAHWJEIZDGL-NWRCXQRFSA-N
Smiles	COc1cc2c3CC4CCCN4Cc3c5cc(OC)c(OC)cc5c2cc1OC.CC6(C)C7CC[C@@]6(C(=O)C7)S(=O)(=O)O
InChI	InChI=1S/C24H27NO4.C9H14O4S/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2;1-8(2)6-3-4-9(8,7(10)5-6)14(11,12)13/h9-12,14H,5-8,13H2,1-4H3;6H,3-5H2,1-2H3,(H,11,12,13)/t;6?,9-/m.0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C33H41NO8S
Molecular Weight	611.75
AlogP	None
Hydrogen Bond Acceptor	None
Hydrogen Bond Donor	None
Number of Rotational Bond	None
Polar Surface Area	None
Molecular species	None
Aromatic Rings	None
Heavy Atoms	None

Assay Description	Organism	Bioactivity
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 100 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection	Tobacco mosaic virus	65.5 %
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 100 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection	Tobacco mosaic virus	55.6 %
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution for 20 min and measured 72 hr post compound treatment by half-leaf method	Tobacco mosaic virus	23.6 ug.mL-1
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 5 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method	Tobacco mosaic virus	32.3 %
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 25 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method	Tobacco mosaic virus	42.4 %
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 50 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method	Tobacco mosaic virus	60.6 %
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 100 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method	Tobacco mosaic virus	73.9 %
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 100 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection	Tobacco mosaic virus	47.7 %

Cross References

Resources	Reference
ChEMBL	CHEMBL2227726
PubChem	53239219

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).