EcoDrugPlus


Synonyms	APR-246 Apr 246 Apr-246 Eprenetapopt PRIMA-1Met
Status
Molecule Category	Free-form
UNII	Z41TGB4080

Synonyms

APR-246

Apr 246

Apr-246

Eprenetapopt

PRIMA-1Met

Status

Molecule Category

Free-form

UNII

Z41TGB4080


InChI Key	BGBNULCRKBVAKL-UHFFFAOYSA-N
Smiles	COCC1(CO)C(=O)C2CCN1CC2
InChI	InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3

InChI Key

BGBNULCRKBVAKL-UHFFFAOYSA-N

Smiles

COCC1(CO)C(=O)C2CCN1CC2

InChI

InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3

Property Name	Value
Molecular Formula	C10H17NO3
Molecular Weight	199.25
AlogP	-0.34
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	49.77
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	14.0

Property Name

Value

Molecular Formula

C10H17NO3

Molecular Weight

199.25

AlogP

-0.34

Hydrogen Bond Acceptor

4.0

Hydrogen Bond Donor

1.0

Number of Rotational Bond

3.0

Polar Surface Area

49.77

Molecular species

NEUTRAL

Aromatic Rings

0.0

Heavy Atoms

14.0

Mechanism of Action	Action	Reference
Cellular tumor antigen p53 stabiliser	STABILISER	Other PubMed PubMed PubMed EMA

Mechanism of Action

Action

Reference

Cellular tumor antigen p53 stabiliser

STABILISER

Other PubMed PubMed PubMed EMA

Resources	Reference
ChEMBL	CHEMBL3186011
DrugBank	DB11684
FDA SRS	Z41TGB4080
SureChEMBL	SCHEMBL2228161

Resources

Reference

ChEMBL

DrugBank

FDA SRS

SureChEMBL

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

EPRENETAPOPT

Structure

Physicochemical Descriptors

Pharmacology

Cross References